DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNX2 and Snx1

DIOPT Version :9

Sequence 1:	NP_003091.2	Gene:	SNX2 / 6643	HGNCID:	11173	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	224/510 - (43%)
Similarity:	313/510 - (61%)	Gaps:	62/510 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    17 DFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEV 81
            :.|..|...|.....::...::.|..|...:||           |..|.||.:..|||
  Fly     2 EVESPEHTRDFAEVDINNGAATGSEDEEEEVPA-----------PGSVTLDRNESDLF------- 48

Human    82 SLDSPEREPILSSEPSPAVTPVTPTTL--IAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEI 144
                              |:.::|:::  |.|..|       |:.|          :||.| |.|
  Fly    49 ------------------VSALSPSSIGDIHPLQE-------VLTD----------DGDYF-ISI 77

Human   145 GVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAP 209
            .||||:|:||||.:|:||:|||||::..|.:||||..||||||||:|..|..||:.:|.|:||||
  Fly    78 VVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAP 142

Human   210 EKSIVGMTKVKVGKEDSS-----STEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLES-SELP 268
            .|:|:|.||||:..:.|.     :.|:||.|||||||::.||.:||.|..|.|...|||| .|||
  Fly   143 SKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLESDQELP 207

Human   269 RAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCH 333
            |:|||.||||||::|:.||..:.|||:|.||:|:|.||::|..:.|:||..|:|||.::::||..
  Fly   208 RSVNTSALSGAGVIRLFNKVGETVNKITYKMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTS 272

Human   334 RKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIR 398
            |:|||..|...|||||||...|:||.||||||.||:|||||:.|..|||.:||::.:|.:.||:.
  Fly   273 RRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLG 337

Human   399 LIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERD 463
            |..|:|.:|..|:|.:|.|:.||:.|.|:||...:..:||:.||:.||:.|:.||:.|||:.::.
  Fly   338 LFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQ 402

Human   464 FEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAI 518
            |:.||..|::|:.|||..||||||..||||:|..:..|||::.|||||.|.|:.|
  Fly   403 FDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQIVSYWEAFAPFAREI 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNX2	NP_003091.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		15/86 (17%)
		Sorting_nexin	2..134	CDD:367612	21/118 (18%)
		PX_SNX2	142..265	CDD:132815	71/128 (55%)
		Interaction with RhoG. /evidence=ECO:0000269\|PubMed:20604901	260..519		133/260 (51%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303\|PubMed:19816406	278..295		8/16 (50%)
		BAR	283..516	CDD:386243	114/232 (49%)
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	70/127 (55%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	110/222 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155296
Domainoid	1	1.000	237	1.000	Domainoid score	I2326
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2332
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1902
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53591
OrthoDB	1	1.010	-	-		D299625at33208
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		otm42219
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	LDO	PTHR10555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X1340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800