DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNX1 and SH3PX1

DIOPT Version :9

Sequence 1:	NP_001229862.1	Gene:	SNX1 / 6642	HGNCID:	11172	Length:	557	Species:	Homo sapiens
Sequence 2:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	107/562 - (19%)
Similarity:	208/562 - (37%)	Gaps:	126/562 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     7 GCSASERLPPPF--PGL-----EPESEGAAGGSEPE-AGDSDT-----------EGEDIFTGAAV 52
            |.::..::|.||  |.|     ..:.:|:....|.: :.|:||           .|:....|..
  Fly    72 GATSVPQVPDPFASPPLPRYDQTADDDGSNWDDEDDWSDDNDTYSEIGPGGQKSAGQSARAGGL- 135

Human    53 VSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKT----L 113
              .|.:.......|||           ..:.:.|.|   |:|.....:....:|.:.||:    :
  Fly   136 --SHSTSDYDNKHLPI-----------APNDDTQSL---ASVAGGTGAAGTVKKGMFAKSSDSYI 184

Human   114 ISLPPQEATNSSKPQPTYEELEEEEQ------EDQFDLTVGITDPEKIG--DGMNAYVAYKVTTQ 170
            :.|   .:|....|:.....:.:.|.      ::....:|.:..|:|..  .||..::||::|
  Fly   185 LGL---SSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLT-- 244

Human   171 TSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFL 235
               |.|.:  .:|.||:..|..|:|:|.:|...  ..|||.|:|.:.|..:          .:|:
  Fly   245 ---PSFNN--ISVSRRYKHFDWLHERLVDKFCL--IPVPPLPDKQISGRYE----------EQFV 292

Human   236 EKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSK-MT 299
            |.||..|:.::..:..||.:.:......||...:       :.:..:|..|........|:. :.
  Fly   293 EHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRD-------EKIWKSGKRKAERDPYMGVNYCLA 350

Human   300 IKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNT---------------AQFAK 349
            |...:.::...:...:||...|.:..:...|..|.|...::|..:               :..||
  Fly   351 ISPPDKNLLHSKVDAQVELGTQFIHSMDVAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAK 415

Human   350 SLAM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFD 411
            :||:   ...:.:...||.::.::..:...|.|...:|..:|:..|::.|..|..:|......|.
  Fly   416 ALAIDERRAPTRNAVPLSESVGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFS 480

Human   412 QRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRK 476
            ......|:.:|.:     |...|.|:   |.|               ::....|..:.:|..|..
  Fly   481 THKGAIQKRKDCE-----KLAGEGRM---NNP---------------QLHDVNRRTDVVSYTVLA 522

Human   477 EVIRFEKEKS-------KDFKNHVIKYLETLLYSQQQAGEQL 511
            |:..|:.|:.       |:|....||:.:.::...|:|..|:
  Fly   523 ELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEASRQI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNX1	NP_001229862.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84		17/95 (18%)
		Sorting_nexin	55..130	CDD:281663	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..142		4/32 (13%)
		PX_SNX1	145..268	CDD:132814	33/124 (27%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303\|PubMed:19816406	281..298		3/17 (18%)
		BAR	286..506	CDD:299863	42/245 (17%)
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697
		PX_SNX9_18_like	219..343	CDD:132772	35/149 (23%)
		BAR_SNX9_like	362..564	CDD:153310	41/224 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940