Protein Alignment SNTB1 and stn-1

DIOPT Version :10

• Sequence 1: XP_054217035.1
• Gene: SNTB1 / 6641
• HGNCID: 11168
• Length: 636
• Species: Homo sapiens
• Sequence 2: NP_492521.1
• Gene: stn-1 / 266844
• WormBaseID: WBGene00006062
• Length: 440
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 183/521 - (35%)
• Similarity: 278/521 - (53%)
• Gaps: 85/521 - (16%)

Human   118 AQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCRGAGAGHPGAGGAQP 182
            |.||||:::.|:.:||:||..|...|:.|.:.|...|
 Worm     3 AVRSGLVDIFVQGQWHRVLATLDPTAITLQTMEQNEA---------------------------- 39

Human   183 PDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAAD 247
                                  ..:||.|:|:|.:..|||||||||::|.|||:|||||||:|||
 Worm    40 ----------------------EAEKRTVRVVKYDGNGLGISIKGGRDNNMPIVISKIFKGMAAD 82

Human   248 QTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWET 312
            |...|::.|.|:||||.:|.||:|:|||:||||||:.|.|:|:|.||  ..:.:.:.|..:.|:.
 Worm    83 QAGELFLDDVIISVNGENLLDASHEEAVRALKRAGRVVDLQVQYRRE--DMMHRENIVENVEWDD 145

Human   313 PPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILR 377
            ...|..|                     :|.||:.||.|:...||.|.|.||:.||..::::.:|
 Worm   146 DIRERVR---------------------TIGLKLAYVARAGIDADAEGRILEMRSPSGRYSLAMR 189

Human   378 SKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPA 442
            ...|..|..||.|:|:....|||:.:|:|...||     .:.::||:||:||:|.......|||.
 Worm   190 CSSSEEADGWFEALHACTTCLLTQALAQVNIMLG-----NNPQVRHMGWIAEQVSENGISMWKPK 249

Human   443 LVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVD--LSFATRTGTRQG 505
            .:.||..::|.|:::|:.|..|..|....||:|||:|.:.........|:.  :||..||||:||
 Worm   250 FMTLTNSEILFYEAVPQLKAEWAEPRLVRPLVATRVVQTSSRTAPVIKGLTDVISFRMRTGTQQG 314

Human   506 IETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEG 570
            :.||..|.||..:|:.|.|::|.|.:.:....:::|..|.::.:.|.|.::.:||.|:.:...|
 Worm   315 VRTHTIRVETHAELARWVRAVVIGGYEACLSTSQVSAPCLWRGESCELIVNLDNGISLLSSTGE- 378

Human   571 AFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLV 635
                .:.|..:|.::.:.|||.|.|::|||...||.:|||.:..||:|||:||||:.|:.||||.
 Worm   379 ----VLWQHSFETIRATGDDGGRFLWVDFGPPHGEQELDLLNSAKPVVFILHSFLATKVYRLGLY 439

Human   636 A 636
            |
 Worm   440 A 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNTB1	XP_054217035.1	PDZ_syntrophin-like	209..291	CDD:467262	51/81 (63%)
		PHsplit_syntrophin	<340..397	CDD:269960	21/56 (38%)
		PH	421..531	CDD:459697	43/111 (39%)
stn-1	NP_492521.1	PDZ_syntrophin-like	44..126	CDD:467262	51/81 (63%)
		PH-like	<152..208	CDD:473070	22/76 (29%)
		PH	228..334	CDD:459697	40/105 (38%)