DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNTB1 and sntb1

DIOPT Version :9

Sequence 1:	NP_066301.1	Gene:	SNTB1 / 6641	HGNCID:	11168	Length:	538	Species:	Homo sapiens
Sequence 2:	XP_012820630.1	Gene:	sntb1 / 100493340	XenbaseID:	XB-GENE-1013041	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	541	Identity:	387/541 - (71%)
Similarity:	440/541 - (81%)	Gaps:	35/541 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSS---EEGAAAYNGIGT 62
            ||||||.|.            |||.||||||.||||||.||.|.:|||||   .|.|.:.|.:..
Frog     1 MAVAAAGAL------------RSGWLEVLVRGRWHKVLGNLYESSLVLSSPERPEDAPSSNSMTN 53

Human    63 ATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISI 127
            .||                    .||.|||||||:||:.|||:|:|:||.|||:|||||||||||
Frog    54 GTN--------------------SSPQGVRTAFTELPDTVPEAIANKKRAVKVVKQELGGLGISI 98

Human   128 KGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVK 192
            |||||||||||||||||||||||||:||||||||:|||.|||||||||||||||:||:||:||||
Frog    99 KGGKENKMPILISKIFKGLAADQTQSLYVGDAILTVNGLDLRDATHDEAVQALKKAGREVILEVK 163

Human   193 YMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMAL 257
            |||||||||||||||||||||||||||||||.::..|||..:.|.|.||||||||||||||||.:
Frog   164 YMREATPYVKKGSPVSEIGWETPPPESPRLGNTSVCPPSPVALSIHGDRKSIPLKMCYVTRSMTV 228

Human   258 ADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSRE 322
            .|||||.||:|||||||||:|||.|..||||||:||||..:||::|||.||:||||||||:||.:
Frog   229 PDPENRNLELHSPDAKHTVVLRSSDPVTAQAWFNAIHSAASDLVSRVITEVKEQLGKTGISGSTD 293

Human   323 IRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGK 387
            |.|||||||||.||::|.||..|:||||||||:||||||.|:||.:|||.|||:|||||||||||
Frog   294 IGHLGWLAEKVLGENEKHWKAVLMVLTEKDLLMYDSMPRMKDAWLNPVHAYPLIATRLVHSGPGK 358

Human   388 GSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQE 452
            .|...|.:.|||||||::||||||.|||||:||||.||||||||||:||||:.||||.|||||.|
Frog   359 ISSLPGTEFSFATRTGSKQGIETHFFRAETNRDLSLWTRSIVQGCHHSAELVKEISTPCTYKNNE 423

Human   453 CRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPK 517
            |||.|:|::||.:|:|..:|.:.:.::|.||||||||||||::||||||||||||:|||||.|||
Frog   424 CRLVINYDHGFLLTSEALDGTYSRPLLQFPYEKLKMSSDDGVKMLYLDFGGKDGELQLDLHCCPK 488

Human   518 PIVFIIHSFLSAKITRLGLVA 538
            |||||||||||||||||||||
Frog   489 PIVFIIHSFLSAKITRLGLVA 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNTB1	NP_066301.1	PDZ_signaling	111..192	CDD:238492	72/80 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..237		22/31 (71%)
		PH	<231..295	CDD:278594	47/63 (75%)
		PHsplit_syntrophin	<242..299	CDD:269960	44/56 (79%)
		PH	323..433	CDD:278594	82/109 (75%)
		PH	323..433	CDD:214574	82/109 (75%)
		Calmodulin-binding. /evidence=ECO:0000250	518..538		19/19 (100%)
sntb1	XP_012820630.1	PDZ_signaling	82..163	CDD:238492	72/80 (90%)
		PHsplit_syntrophin	<205..270	CDD:269960	48/64 (75%)
		PH	296..401	CDD:365918	78/104 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I17746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9618
Inparanoid	1	1.050	765	1.000	Inparanoid score	I4759
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D115047at32523
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		oto159656
Panther	1	1.100	-	-	LDO	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110