DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhrs7 and CG31937

DIOPT Version :9

Sequence 1:	NP_079798.2	Gene:	Dhrs7 / 66375	MGIID:	1913625	Length:	338	Species:	Mus musculus
Sequence 2:	NP_608616.2	Gene:	CG31937 / 326177	FlyBaseID:	FBgn0031360	Length:	321	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	110/300 - (36%)
Similarity:	162/300 - (54%)	Gaps:	18/300 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 ELLLWLLALCALILPLVQLLRFLRADADLTLLWAEWQGRRPEWELTDM---VVWVTGASSGIGEE 65
            |.||.||.|..::..|:.:|    .|.::.|    |...|....|:.|   |||:||||||||..
  Fly     5 EFLLLLLVLYYVVYVLLWIL----LDCNVAL----WYKSRFGVSLSSMRGQVVWITGASSGIGRA 61

Mouse    66 LAFQLSKLGVSLVLSARRAQELERVKRRCL--ENGNLKEKDILVLPLDLTDTSSHEAATKAVLQE 128
            ||..|::.||.|||||||.::||:|:..||  ..|.|..||:||:.:|:.|...|:.....||..
  Fly    62 LALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDVLVIQMDMLDLDEHKTHLNTVLNH 126

Mouse   129 FGKIDILVNNGGRSQRSLVLETNLDVFKELINLNYIGTVSLTKCVLPHMIERK--QGKIVTVNSI 191
            |.::|:||||.|||||:...|..::|.:||..|:....|.|::.|:.:.:|:.  :|.|...:||
  Fly   127 FHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAVVHLSRLVVRYFVEQNGGRGHIAATSSI 191

Mouse   192 AGIASVSLSSGYCASKHALRGFFNALHSELGQYPGITFCNVYPGPVQSDIVKNAFTEEVTKSMRN 256
            ||.:.|..|..|||:||||..:..:|..|:.:.....|.   |||:.:|.::.|||......:..
  Fly   192 AGFSPVPFSPTYCAAKHALNAYLLSLKVEMRKLDVSLFA---PGPIATDFLQEAFTGSQGGKVGL 253

Mouse   257 NIDQSYKMPTSRCVRLMLISMANDLKEVWISDHPVLLGAY 296
            :.....:|...||..|..:::||.:...|....||.|.||
  Fly   254 STANQKRMTAQRCGDLFAVALANKMDLTWCGLFPVNLLAY 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs7	NP_079798.2	11beta-HSD1_like_SDR_c	48..308	CDD:187593	97/255 (38%)
Dhrs7	NP_079798.2	adh_short	52..249	CDD:278532	84/200 (42%)
CG31937	NP_608616.2	NADB_Rossmann	44..293	CDD:304358	95/251 (38%)
CG31937	NP_608616.2	adh_short	47..245	CDD:278532	83/200 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850738
Domainoid	1	1.000	153	1.000	Domainoid score	I4281
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9350
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4075
Isobase	1	0.950	-	0	Normalized mean entropy	S2709
OMA	1	1.010	-	-		QHG59790
OrthoDB	1	1.010	-	-		D429842at33208
OrthoFinder	1	1.000	-	-		FOG0004121
OrthoInspector	1	1.000	-	-		otm43117
orthoMCL	1	0.900	-	-		OOG6_104960
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5576
SonicParanoid	1	1.000	-	-		X68
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.650