Protein Alignment SNRPA1 and U2A

DIOPT Version :10

• Sequence 1: NP_003081.2
• Gene: SNRPA1 / 6627
• HGNCID: 11152
• Length: 255
• Species: Homo sapiens
• Sequence 2: NP_610315.1
• Gene: U2A / 35713
• FlyBaseID: FBgn0033210
• Length: 265
• Species: Drosophila melanogaster
• Alignment Length: 264
• Identity: 136/264 - (51%)
• Similarity: 178/264 - (67%)
• Gaps: 20/264 - (7%)

Human     1 MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRR 65
            |||||.|||.|:.||.|..|:|||||||||||.||||||||||||.||.|||::||||..|.|.|
  Fly     1 MVKLTPELINQSMQYINPCRERELDLRGYKIPQIENLGATLDQFDTIDLSDNDLRKLDNLPHLPR 65

Human    66 LKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKH 130
            ||.||:|||||.||.|||::|:|.|..:|||.|:|.||.||:||.....|..:.:|.|||:.|.:
  Fly    66 LKCLLLNNNRILRISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKLETICLLINPVSTKPN 130

Human   131 YRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDK---- 191
            ||.|:.||.||:|:|||:|:|.|:||.|::.|:.|:|..:.|:|:|:|| .:..|.:..:.
  Fly   131 YREYMAYKFPQLRLLDFRKIKQKDRQAAQEFFRTKQGKDVLKEISRKSK-MSAAAAIAAEAGNGK 194

Human   192 ---KKGG--PSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTV 251
               .:||  .:|.|::.|:.||..||:|||||||..:|||||:|         |..:.|||. ..
  Fly   195 GRGSEGGRLANPQDMQRIREAIKRASSLAEVERLSQILQSGQLP---------DKFQHEMEA-VA 249

Human   252 TNGS 255
            .||:
  Fly   250 QNGA 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNRPA1	NP_003081.2	LRR_9	1..175	CDD:405295	103/173 (60%)
		LRR 1	20..41		18/20 (90%)
		leucine-rich repeat	22..43	CDD:275378	19/20 (95%)
		LRR 2	43..64		13/20 (65%)
		leucine-rich repeat	44..65	CDD:275378	13/20 (65%)
		LRR 3	65..86		15/20 (75%)
		leucine-rich repeat	66..89	CDD:275378	15/22 (68%)
		LRR 4	89..110		11/20 (55%)
		leucine-rich repeat	90..114	CDD:275378	12/23 (52%)
		leucine-rich repeat	115..127	CDD:275378	5/11 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..255		11/32 (34%)
U2A	NP_610315.1	LRR_9	1..175	CDD:405295	103/173 (60%)
		leucine-rich repeat	22..43	CDD:275380	19/20 (95%)
		leucine-rich repeat	46..65	CDD:275378	11/18 (61%)
		leucine-rich repeat	66..89	CDD:275378	15/22 (68%)
		leucine-rich repeat	90..114	CDD:275378	12/23 (52%)