Protein Alignment SNAPC4 and Pbp95

DIOPT Version :10

• Sequence 1: NP_003077.2
• Gene: SNAPC4 / 6621
• HGNCID: 11137
• Length: 1469
• Species: Homo sapiens
• Sequence 2: NP_649760.1
• Gene: Pbp95 / 40949
• FlyBaseID: FBgn0037540
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 138/657 - (21%)
• Similarity: 238/657 - (36%)
• Gaps: 177/657 - (26%)

Human    52 DPADPPISEEERWGEASNDEDDPKDKTLPEDPETCLQLNMVYQ----EVIQEKLAEANLLLAQNR 112
            |..|..|::::...|.|    .....|........||||...|    :|..:.||...::.|:..
  Fly     3 DADDLRINQQQLMDEIS----ALLQNTAKPSAANALQLNQELQRRLMQVRTKILAMLQVVRARFS 63

Human   113 EQQEELMR-------------DLAGS---KGTKVKDGKSLPPSTYMGHFMKPYFKDKVTGVGPPA 161
            ..::.|:|             :|:|:   |||          ..:.|:.   :|:| :.|...|.
  Fly    64 RNEDILVRRLRPRSHFGPNSLNLSGAILRKGT----------FRFKGNL---FFRD-IDGRSCPN 114

Human   162 NEDTREKAAQGIKAFEELLVTKWKNWEK----ALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKV 222
            |||..      .:...|:..|.:....:    .|.:|:|:....|:||:.:      .|...:..
  Fly   115 NEDYE------ARCHTEMFPTDFDMHSRHVWTLLDKKNVIMGIKQQLLEHR------AHSTNALP 167

Human   223 SSELERQALEKQGREAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNS 287
            |..|:|:.:|:.          ::.|.......:...|.||.:||.::.|...|.......|:..
  Fly   168 SGSLKRKPIERH----------LSTLVSLLATADSSFSIDWNQISTLDLEYRHSPYSCEAMWRVY 222

Human   288 EHPSINKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKAL----KRKE 348
            ..|.:.:.:||.||:|.|.|:|.|:....|:.||..| ..||.:||..:|....:.|    ....
  Fly   223 LTPDLRRDDWSPEEDETLLAVATANRMQNWELIAASL-DRRSDYQCFVRFHTALRFLLEPKNSHR 286

Human   349 WTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLL 413
            |:||::..|..:|......|.|.::::|.|...:....||.|:...|.|.:....:..:||..|.
  Fly   287 WSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMMLF 351

Human   414 QAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAK 478
            .||.:|..:.....|...|.||..|.|.||...|....|...|:::::.:|:..:.:||...|..
  Fly   352 AAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDSWSVQDDTRLMSFVTQYGASQWLN 416

Human   479 IASELPHRSGSQCLSKWKIMM--------GKKQGLRRRRRRARHSVRWSSTSSSGSSSGSSGGSS 535
            .|:.|.:.:.:.|.:::.::.        .|.:.|.|||                         |
  Fly   417 CATFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRR-------------------------S 456

Human   536 SSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSP 600
            ...|..:.::..::.|..:.|     |:.:|.|                              :|
  Fly   457 KKVSLVNSDNWAQRLQEWQED-----PESLVND------------------------------NP 486

Human   601 PKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRR 665
            |||:                            |..||..:.|:           .|:|| |...|
  Fly   487 PKGT----------------------------RVRGPKSKKAR-----------IERQA-ESFSR 511

Human   666 LLTVPVE 672
            |..|.:|
  Fly   512 LSKVDIE 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNAPC4	NP_003077.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..82		6/29 (21%)
		SNAPC5-binding. /evidence=ECO:0000269|PubMed:11056176	84..133		16/68 (24%)
		SANT	<262..305	CDD:473887	13/42 (31%)
		Myb_DNA-bind_6	297..357	CDD:372817	22/63 (35%)
		SANT	346..397	CDD:197842	13/50 (26%)
		PLN03091	399..>502	CDD:215570	24/110 (22%)
		SANT	401..448	CDD:197842	14/46 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..558		9/56 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..661		11/83 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..710
		PHA03247	<817..1215	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..894
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	932..981
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1001..1051
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1167
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1184..1266
		SNAPC2-binding. /evidence=ECO:0000269|PubMed:11056176	1281..1393
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1430..1449
Pbp95	NP_649760.1	SANT	<194..240	CDD:473887	14/45 (31%)
		SANT	229..276	CDD:197842	18/47 (38%)
		Myb_DNA-bind_6	287..350	CDD:372817	16/62 (26%)
		SANT	392..438	CDD:197842	8/45 (18%)