DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNAPC4 and Myb

DIOPT Version :9

Sequence 1:	NP_001381130.1	Gene:	SNAPC4 / 6621	HGNCID:	11137	Length:	1469	Species:	Homo sapiens
Sequence 2:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	155/736 - (21%)
Similarity:	248/736 - (33%)	Gaps:	250/736 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   274 SRSAEEIRKFWQNSEHPSINKQEWSREEEERL------QAIAAAHGH-LEWQKIAEELGTSRSAF 331
            :.:.||:..:..||:.   .:.|:|..|:.::      |...|..|: |:    :.||..|::..
  Fly     6 TENGEELMNYGSNSDS---EESEYSENEDTQVCDKDSQQNSNADSGYPLD----SPELQDSKTTG 63

Human   332 QCLQKFQQHNKALKR------------KEWTEEEDRMLTQLVQ------EMRVGSHIPYRRIVYY 378
            |     :..||:.|.            |.|::.||.:|.|||:      |: :|.|
  Fly    64 Q-----KGQNKSGKTSIGAVHPNYGFGKRWSKSEDVLLKQLVETHGENWEI-IGPH--------- 113

Human   379 MEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRY 443
            .:.|...|:..||.|.|:|.|.||.|..:||..:::.|..:|.:.|..|...:.||...|||:|:
  Fly   114 FKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERW 178

Human   444 LRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGLRRR 508
            ...|:.::||..|..||:|.:.:...:.| ..|||||..||.|:.:...:.|...|.:|..:.||
  Fly   179 HNHLNPNIKKTAWTEKEDEIIYQAHLELG-NQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERR 242

Human   509 RRRARHSVRWSSTSSSGSSSGS----------SGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQ 563
                       |.::|||...|          |||.|...::.....|.
  Fly   243 -----------SVNASGSDLKSSRTHLITLIKSGGISKCMNNMQHNKES---------------- 280

Human   564 YMVPDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSPPKGSSASQGGSKEASTTAAAPGEETSPV 628
                                        ||.|.:.|.         .:..||.||...|:
  Fly   281 ----------------------------GGEAVNKSE---------NADGASVTAVKGGD----- 303

Human   629 QVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRRLLTVPVET--VLRVLRANTA----ARSC 687
                     :.:.:|..|...:..|....|.|    ..||:|.:|  :|:..|.:..    ...|
  Fly   304 ---------LAQESQDDHQKGSNLAHLSMQHL----IKLTMPRQTPIILKRTRKHIPETHHQAGC 355

Human   688 TQKEQLRQPPL-------PTSSPGVSSGDSVARSHVQWLRHRATQSGQRRWRHALHRRLLNRRLL 745
            :..|...|...       |.|||.:|...|:..|...:|:.
  Fly   356 SSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFLKS------------------------ 396

Human   746 LAVTPWVGDVVVPCTQASQRPAVVQTQAD-GLREQLQQARLASTPVFTLFTQLFHIDTAGCLEVV 809
                        ||         :.|..| .||        |||||..::.::       .:|:.
  Fly   397 ------------PC---------LTTFEDMDLR--------ASTPVTKVYNRV-------GMEIK 425

Human   810 RERKAL---PPRLPQAGARDPPVHLLQASSSAQSTPGHLF-PNVPA------------QEASKSA 858
            :|.:..   .|...|.|.|.|.......::..:...|..: |:.|:            :..|.|.
  Fly   426 KEMETSSIETPHKSQLGPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAEIIHEEHLSNSL 490

Human   859 SHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELL-----------QEKRLQEARAREATR 912
            :...|:.:.::....|| .....|.:.|..|....|.|.           ..||:|.....
  Fly   491 TANNSKMMGAADQNSTL-STEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSAKRIQPFETE---- 550

Human   913 GPVVLPSQLLVSSSVILQPPL 933
                .||:.|.|...||:..|
  Fly   551 ----TPSKFLTSPGDILKDTL 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNAPC4	NP_001381130.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..82
		SNAPC5-binding. /evidence=ECO:0000269\|PubMed:11056176	84..133
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..558		13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..661		13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..894		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..981		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1051
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1184..1266
		SNAPC2-binding. /evidence=ECO:0000269\|PubMed:11056176	1281..1393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1430..1449
Myb	NP_511170.1	SANT	85..132	CDD:197842	17/56 (30%)
		Myb_DNA-bind_6	88..147	CDD:290632	23/68 (34%)
		SANT	136..184	CDD:197842	16/47 (34%)
		Myb_DNA-bind_6	139..197	CDD:290632	19/57 (33%)
		SANT	188..235	CDD:197842	16/47 (34%)
		Myb_DNA-binding	188..233	CDD:278669	15/45 (33%)
		Cmyb_C	388..530	CDD:286408	33/202 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850