Protein Alignment POLR3D and Polr3D

DIOPT Version :10

• Sequence 1: NP_001713.2
• Gene: POLR3D / 661
• HGNCID: 1080
• Length: 398
• Species: Homo sapiens
• Sequence 2: NP_649028.3
• Gene: Polr3D / 40002
• FlyBaseID: FBgn0036775
• Length: 415
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 108/443 - (24%)
• Similarity: 176/443 - (39%)
• Gaps: 107/443 - (24%)

Human     2 SEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGG-----VKKKTFTPN 61
            :.|:......:.||.|||.| ..|:....||             |||||||     ..||.|.||
  Fly    19 ASGSTTNNGQSGGGARPLET-LNGMTRLTPA-------------RDLTLGGRGAGTASKKVFAPN 69

Human    62 IISRKIKE---EPKEEVTVKKEKRERDR------DRQREGHGRGRGRPEVIQSHSIFEQGPAEMM 117
            :.:.:.|.   :..::.|..:..|...|      .|.|.|:..|.|...:||:..:|.:|..::.
  Fly    70 LNAVRNKNANVKTSKDTTQPRSGRRGGRGNGTGATRGRGGNSAGGGNSTLIQTQGLFSEGAGDVH 134

Human   118 KKKGNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQLPL 182
            .::...:.|..........:...:.::::...:.::|..:|.:.|
  Fly   135 VRRSTGNGTAYARGGEEVSVTRKRVDRKDDKSQAERIKELLGESD-------------------- 179

Human   183 AHSGWLFKEENDEPD--VKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAARKTPGL 245
            |..|.|.:||.::.:  ::|.|.   :|.:.|.......|:|               .|..|..|
  Fly   180 ASGGELSEEEANKTEMALRPILL---KEGLWVTQKTPIAKQE---------------IASSTSTL 226

Human   246 PKDVSVAELLRELSL--------------------------TKEEELLFLQLPDTLP--GQPPTQ 282
            ...::||:.|::|.:                          :.|.::..:||||.||  |. .::
  Fly   227 KDTLAVAQHLQQLHVAAQAASLEEPPLQYGRYPRTIGNFLDSSEAQIFLMQLPDVLPCVGD-DSE 290

Human   283 DIKPIKTEVQGEDGQVVLIKQEKDREAKLAEN---ACTLADLTEGQVGKLLIRKSGRVQLLLGKV 344
            |.:|.|.:.|...      :.|....|....|   ...|..|.|||:||:|..|||||:|.||..
  Fly   291 DPEPSKGDHQATS------ESEPASPADKCSNGPKGSVLRQLEEGQIGKILRYKSGRVKLQLGDT 349

Human   345 TLDVTMGTACSFLQELVSVGLG-DSRTGEMTVLGHVKHKLVCSPDFESLLDHK 396
            ..|:.||....|||||:||... :.|:|.|..||.::.||..:||:..|...:
  Fly   350 RFDLDMGLDPGFLQELMSVTANREQRSGNMINLGPIQAKLKATPDWVHLFQQQ 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLR3D	NP_001713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..114		35/125 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..244		4/23 (17%)
		RNA_pol_Rpc4	263..389	CDD:461558	49/131 (37%)
Polr3D	NP_649028.3	RNA_pol_Rpc4	270..395	CDD:461558	49/131 (37%)