DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMPD1 and smpd1

DIOPT Version :10

Sequence 1:NP_000534.3 Gene:SMPD1 / 6609 HGNCID:11120 Length:631 Species:Homo sapiens
Sequence 2:NP_001313465.2 Gene:smpd1 / 556700 ZFINID:ZDB-GENE-110411-222 Length:591 Species:Danio rerio


Alignment Length:553 Identity:324/553 - (58%)
Similarity:399/553 - (72%) Gaps:15/553 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    77 VPRLRDV---------FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAV 132
            ||:||.|         |||.||:|.:||.:|.::::.|..:.|:.||.....::|..|.:|.|.|
Zfish    33 VPQLRVVEELDRLKLGFGWRNLSCVLCKAIFASVDIALLSDSNMERVSRALGEVCVRLHLANPDV 97

Human   133 CQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPG 197
            |:.|..||..|::...:.|.|.|:|||.:|:|.:|||:||::.||:|||.:||||.||||||.||
Zfish    98 CRDITALFRADVIRALQESFLWPTEACAVLVGPSCGHFDIYAPWNVSLPQIPKPPVKPPSPPKPG 162

Human   198 APVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESL 262
            :|.||||||||:|||.:|.||:..:|..|||||..||.......||||||.||||||||||:|:|
Zfish   163 SPRSRILFLTDIHWDAEYTEGSLAECNKPLCCRNDSGRASWRHAGAGYWGTYSKCDLPLRTVENL 227

Human   263 LSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLG-PVPVYPAVGNHESTPV 326
            |..:..:||:|.||||||||||:||.|||..||..|.|::.|:.|.|| .|.|||||||||||||
Zfish   228 LENVAKSGPWDWVYWTGDIPAHNVWSQTRNQQLNELVTISRLIHKHLGRNVTVYPAVGNHESTPV 292

Human   327 NSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSREN 391
            |||||||:.||||||||||.|||.|.||||.|||.|:|.||||::...|||||:|||||||||||
Zfish   293 NSFPPPFVHGNHSSRWLYETMAKEWAPWLPEEALETIRRGGFYSVEVEPGLRLVSLNMNFCSREN 357

Human   392 FWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQF 456
            :||::||||||.|||||:..||.:|::|:|||||||||||.||.|||||||.||.|||:|:..||
Zfish   358 YWLMVNSTDPADQLQWLIQILQESENKGEKVHIIGHIPPGFCLSSWSWNYYHIVNRYESTITGQF 422

Human   457 FGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIL 521
            |||||.|||::|||||||:|||:|||:|||.||::.||||||||.:||||..||.:||||||:||
Zfish   423 FGHTHTDEFQMFYDEETLTRPLSVAFIAPSVTTFVNLNPGYRVYYVDGNYPDSSRMVLDHETFIL 487

Human   522 NLTQAN----IPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPP 582
            |||.||    .|...|.|.|||||.|.|||....|:....|:..|..|.::||.||:|:|||| .
Zfish   488 NLTLANNRPLKPDPRPSWTLLYRASEAYGLSTLFPSDMEALIKHMVNDDRIFQQFWYLFHKGH-V 551

Human   583 SEPCGTPCRLATLCAQLSARADSPALCRHLMPD 615
            |:||...|:.:.:|...|.|.|....|..|..|
Zfish   552 SKPCTDTCKTSIICFLHSGRYDLLTQCSPLHGD 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMPD1NP_000534.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
SapB 89..162 CDD:214797 25/72 (35%)
MPP_ASMase 203..498 CDD:277321 204/295 (69%)
ASMase_C 476..597 CDD:466022 67/124 (54%)
smpd1NP_001313465.2 None
Blue background indicates that the domain is not in the aligned region.

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