Protein Alignment SMPD1 and CG15534

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_651792.1
• Gene: CG15534 / 43613
• FlyBaseID: FBgn0039769
• Length: 666
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 172/538 - (31%)
• Similarity: 256/538 - (47%)
• Gaps: 30/538 - (5%)

Human    91 CPICKG-------LFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVW 148
            |.:|:.       .||...|...:..:.|:  .:.:.:|:...|:...||..:..|....:..:.
  Fly    99 CTLCRSTINVFARTFTEGELSGPERDDEAK--KLMLGMCDYFAISTQEVCSGLFDLNWPILDFIL 161

Human   149 RRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSP-PAPGAPVSRILFLTDLHWD 212
            ..:|...:..|.:|....|....  ..:|::|......|.:..|. ||..:....:|.|||:|:|
  Fly   162 NETVAKSNTFCSMLPIPICQVKQ--DEYNLTLSIQGDLPQESNSNLPAKTSEDILVLHLTDIHYD 224

Human   213 HDYLEGTDPDCADPLCCRRGSGLPPA--SRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMV 275
            .:|.||::..|.:|:|||  :.||..  |...||:|.:|..||.|.|.:.|....:......:.:
  Fly   225 PEYAEGSNAACDEPMCCR--NSLPEGSDSSAAAGFWSDYRDCDCPKRLILSAFEHIKENHKIEWI 287

Human   276 YWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSS 340
            |.|||:|.|:||..|||..|..|:.:..|:.|:....|:||.:||||..|.|.|....|..:...
  Fly   288 YHTGDVPPHNVWSTTRQGNLDMLSEIDELLAKYFPDTPIYPCLGNHEPHPANVFGNDEIPSSLRV 352

Human   341 RWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQL 405
            .||||.:...|..||||||..|:..||:|..||..|.|:::||...|...|:||..|:|....||
  Fly   353 DWLYEHVWSLWSKWLPAEAEETVLRGGYYTASPSKGHRIVALNSMDCYLYNWWLFYNATLIQEQL 417

Human   406 QWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVF 468
            ||....|.:||:.|:.|||:.|||  .|.|..:||..|.|::.|:...:...|.||||.||..:.
  Fly   418 QWFHDTLLSAEEAGESVHILTHIPAGDGDCWCNWSQEYNRVLTRFNGIITGVFSGHTHKDEMNLH 482

Human   469 YDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQI-DGNYSGSSHVVLDHETYILNLTQANI-PGA 531
            |.|:..:  ..|.:...|.|:|...||.||:|:: ..|:.     ||||.||..|||:||: |..
  Fly   483 YSEDGYA--TVVNWNGGSLTSYSNKNPNYRLYELHPENWQ-----VLDHHTYTFNLTEANLTPDE 540

Human   532 IPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPP--SEPCGTPCRLAT 594
            .|.|:|.|:..:.| ..:|.|.....|:..|.....|.:.||........|  :|.|...|...|
  Fly   541 QPKWELEYQFTKEY-TEDTSPAGIDRLLLEMAEKPDLLRKFWRNKFTNSDPKLAEGCDNACLSKT 604

Human   595 LCAQLSARADSPALCRHL 612
            :|...::.......|:.|
  Fly   605 ICRIATSNYQERTRCKEL 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797	13/77 (17%)
		MPP_ASMase	203..498	CDD:277321	115/298 (39%)
		ASMase_C	476..597	CDD:466022	39/124 (31%)
CG15534	NP_651792.1	MPP_ASMase	215..510	CDD:277321	115/298 (39%)
		ASMase_C	502..619	CDD:466022	37/122 (30%)