Protein Alignment SMPD1 and CG15533

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_651791.2
• Gene: CG15533 / 43612
• FlyBaseID: FBgn0039768
• Length: 692
• Species: Drosophila melanogaster
• Alignment Length: 623
• Identity: 182/623 - (29%)
• Similarity: 277/623 - (44%)
• Gaps: 72/623 - (11%)

Human    33 MGLVLALALALALALALS------------DSRVLWAPAE--------------------AHPLS 65
            :|::||:||.....:..:            |..:|.|.|:                    |..|.
  Fly     4 IGILLAIALTSGFLVVSAVNLPGVPVDFDLDDHILSAIADDIAERLAREYITFLKTGVETAEFLK 68

Human    66 PQGHPARLH-------RIVPRL--RDVFGWGNLTCPICKGLFTAINLGLKKEP-------NVARV 114
            .....|:.|       |.:|.|  ||.|    ..|..|:.:...:...:::|.       :...:
  Fly    69 LTNQLAKSHSEKDIFTRNMPDLEPRDSF----FACVACRSVTRVLIRTIREEDGELHGENSSVLM 129

Human   115 GSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLG----STCGHWDIFSS 175
            ...|:.:|..|.:....||:.::......:..:.|.|.......|.|.:.    :|..:.|.  :
  Fly   130 KEFAMDVCRRLNLQTEEVCEGLIDSNLPSVEYIMRNSESDSQSFCSLFMEFNFCNTGTNQDY--N 192

Human   176 WNISLPTVPKPP--PKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPA 238
            |.:::....:..  ||..:|....:.: ||...:|:|.|..|..|:...||:|:||:|.......
  Fly   193 WTLTIDNTGEASAGPKSDTPTFQDSDI-RICQFSDIHHDPYYTPGSLATCAEPMCCQRNKETTEG 256

Human   239 SRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTA 303
            :...|||||:|..||||....||.|.........|.:|.||||..|.||..:.:.....||.|:.
  Fly   257 TSDAAGYWGDYRDCDLPWHAFESALDNAVANSKCDFIYQTGDIVDHMVWATSVEKNTMVLTKVSE 321

Human   304 LVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGF 368
            .:....|.|||||.:||||..|:|.|.|..:....|::||||.:...|..|||||...|:..||:
  Fly   322 RLNAAFGDVPVYPCIGNHEPHPLNLFSPEGVPDEISTKWLYEHLYNDWSKWLPAETKETILKGGY 386

Human   369 YALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGH- 432
            |.:.|..|.|:|:||.|.|..:||||..:.||...||||....|..||..|:.||::.|||.|.
  Fly   387 YTVVPRKGFRIIALNSNDCYTDNFWLYHSGTDKIPQLQWFHDTLLEAEKNGEYVHVLTHIPSGDG 451

Human   433 -CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPG 496
             |...|:..:.|.|:|:.:|::..|.||:|.||..|:|.|:. ..|.|||:...:.|||...||.
  Fly   452 TCWSVWAREFNRCVSRFRSTISGIFTGHSHKDELFVYYSEDE-GHPTAVAWNGGAVTTYSNKNPN 515

Human   497 YRVYQIDGNYSGSSHVVLDHETYILNLTQANI-PGAIPHWQLLYRARETYGLPNTLPTAWHNLVY 560
            ||.|.:    :..::.|.:|.|:|.|||.||: |...|.|.|.|...:.: ..:..|.....|:.
  Fly   516 YREYAV----NPETYTVTNHWTWIYNLTAANLKPDEQPEWFLEYEFIKEF-TEDMSPAGISKLLD 575

Human   561 RMRGDMQLFQTFWFLYHKGHPP--SEPCGTPCRLATLC 596
            ....:.:|.:.:|........|  :..|...|...:||
  Fly   576 EFAENPELMRKYWRYRVTSADPQVNGGCDRSCLAGSLC 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797	11/79 (14%)
		MPP_ASMase	203..498	CDD:277321	118/296 (40%)
		ASMase_C	476..597	CDD:466022	35/124 (28%)
CG15533	NP_651791.2	SapB	99..183	CDD:214797	12/83 (14%)
		MPP_ASMase	221..517	CDD:277321	118/296 (40%)
		ASMase_C	509..613	CDD:466022	27/108 (25%)