DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMPD1 and CG3376

DIOPT Version :10

Sequence 1:NP_000534.3 Gene:SMPD1 / 6609 HGNCID:11120 Length:631 Species:Homo sapiens
Sequence 2:NP_001246491.1 Gene:CG3376 / 37884 FlyBaseID:FBgn0034997 Length:764 Species:Drosophila melanogaster


Alignment Length:680 Identity:254/680 - (37%)
Similarity:362/680 - (53%) Gaps:91/680 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    29 GLLWMGLVLALAL-------ALALALALSDSRVLWA------------PAEAHP-LSPQGHPARL 73
            |..|:.|||...|       ||.........::.|.            |....| |.|..||.|.
  Fly    50 GKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRT 114

Human    74 HR----------IVPRL---------------RDVFGWGNLTCP--------------------- 92
            ||          .:.||               .||.|...|..|                     
  Fly   115 HRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIEN 179

Human    93 --ICKGLFTAINLG---LKKEPNVARVGSVAIKL----CNLLKIAPPAVCQSIVHLFEDDMVEVW 148
              :.|...||...|   |:.:....:..:..|::    |..|.|....|||.:..||..:::.|.
  Fly   180 SVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVL 244

Human   149 RRSVLSPSEACGLLLGSTCGHWDIFS---SWNISLPTVPKPPPKPPSP-PAPGAPVSRILFLTDL 209
            :|..|||.|.|..::|..|.  |:::   .|.:..|.|||||..|..| |...||..::|.::|.
  Fly   245 KRVNLSPDELCSFVIGDGCA--DVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDT 307

Human   210 HWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPA-GPFD 273
            |:|..|.||::.||.:|||||..||.|......||.||:|.|||.|.||::.:||.:... ...|
  Fly   308 HYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDID 372

Human   274 MVYWTGDIPAHDVWHQTRQDQLRAL-TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFI-EG 336
            .:.||||:|.||||:||:::.|..: .||..:|..|.| ||::||:|||||.||||||||:: :.
  Fly   373 YILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPG-VPIFPALGNHESAPVNSFPPPYVNQV 436

Human   337 NHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDP 401
            :.|..|||:.:...|..|||.....|:|.|.||::...||.|:||||||:|:.:|:|||:|||||
  Fly   437 DISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP 501

Human   402 AGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--CLKSWSWNYYRIVARYENTLAAQFFGHTHVDE 464
            |.:|||.:.|||:||...:|||:||||||||  |||.||.|:|:|::|||:|:.|||:||||.||
  Fly   502 ATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDE 566

Human   465 FEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIP 529
            ||:|||...|:.|..:|::.||.:.|..||||||:|.:||::..::.:|:|||::|:||.:||:.
  Fly   567 FEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLY 631

Human   530 GAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLAT 594
            | .|.|..||.||..|.:....|:.|:||:..:..:.:||:.::..|.|..|....|...|:...
  Fly   632 G-YPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRL 695

Human   595 LCAQLSARA-DSPALCRHLMPDGSLPEAQS 623
            :|...|.|: |....|..:  :..:.|..|
  Fly   696 ICDCRSGRSHDRKHFCAEV--ESKIDEESS 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMPD1NP_000534.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
SapB 89..162 CDD:214797 23/102 (23%)
MPP_ASMase 203..498 CDD:277321 153/299 (51%)
ASMase_C 476..597 CDD:466022 42/120 (35%)
CG3376NP_001246491.1 SapB 186..258 CDD:214797 20/71 (28%)
MPP_ASMase 301..600 CDD:277321 153/299 (51%)
ASMase_C 584..697 CDD:466022 40/113 (35%)
Blue background indicates that the domain is not in the aligned region.

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