Protein Alignment SMPD1 and CG32052

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_729555.4
• Gene: CG32052 / 326184
• FlyBaseID: FBgn0044328
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 503
• Identity: 135/503 - (26%)
• Similarity: 194/503 - (38%)
• Gaps: 127/503 - (25%)

Human   194 PAPGAPVSRILFLTDLHWDHDYLEGTDPD----CADPLCCRRGSGLPPASRPGAGYWGEYSKCDL 254
            |...|.:.....::|||.|..|  .|..|    |.:......||....|:....|.:|.|: ||.
  Fly    19 PGAQARIGYFWHISDLHLDTLY--STQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYN-CDS 80

Human   255 PLRTLESLLSGL--GPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPA 317
            |.|.:||.:..:  ......:.|.||||..:|.....:.|.|...|..:|.|:.:......::|.
  Fly    81 PWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITELLGRSFSSQFIFPV 145

Human   318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLIS 381
            :| ||            :|:.|    |..:.:.|..|||:|||.|...||:|::..... ||:::
  Fly   146 LG-HE------------DGSGS----YRRLGELWRHWLPSEALVTFDQGGYYSIEQTKSRLRIVA 193

Human   382 LNMNFCSRENFWLLINSTDPAGQLQ-------------------------------WLVGELQAA 415
            ||.||..      |....||...|.                               ||...|..:
  Fly   194 LNTNFMR------LDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKS 252

Human   416 EDRGDKVHIIGHIPPG---------HCLKSW----SWNYYRIVARYENTLAAQFFGHTHVDEFEV 467
            :::.:.|:|:||:|||         |...::    :..|..:|.|:...:..|||||.|.|.|.:
  Fly   253 KEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQGQFFGHLHSDTFRL 317

Human   468 FYDEETLSRPLAVAFLAPSAT---TYIGL--NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQAN 527
            .||.:  ..|::...:|||..   ..||.  ||..|:|:.|   :||.. |||:..:.|:|..||
  Fly   318 IYDAK--GNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFD---TGSGQ-VLDYTQFWLDLPLAN 376

Human   528 IPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFL---------YHKGHPP 582
            .... |.||..|.....|.||.....|.||...|..| |:.     ||.         ||.|
  Fly   377 RANE-PTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLS-----WFTRYHRANAVRYHSG--- 432

Human   583 SEPCGTPCRLATLCA----------------QLSARADSPALCRHLMP 614
             ..|...|.|...||                ||:.:..:||.   |||
  Fly   433 -SACPGLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAA---LMP 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797
		MPP_ASMase	203..498	CDD:277321	91/350 (26%)
		ASMase_C	476..597	CDD:466022	41/135 (30%)
CG32052	NP_729555.4	MPP_ASMase	28..351	CDD:277321	91/350 (26%)
		ASMase_C	324..462	CDD:466022	43/151 (28%)