Protein Alignment SMPD1 and Smpd1

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_001006998.1
• Gene: Smpd1 / 308909
• RGDID: 1549719
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 521/633 - (82%)
• Similarity: 559/633 - (88%)
• Gaps: 8/633 - (1%)

Human     1 MPRYGASLRQSCPRSGREQGQDGTAGAP--GLLWMGLVLALALALALALALSDSRVLWAPAEAHP 63
            ||.:|||..|...|:|.||..:.:..||  ||||||      |.|||.|||.||.|||.||.|:|
  Rat     1 MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMG------LGLALVLALFDSTVLWVPARAYP 59

Human    64 LSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIA 128
            |..|||..:...:.|:|::.|||.|||||.||.||||:|.|||||||||||||||||:|.:|.||
  Rat    60 LPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKKEPNVARVGSVAIKMCKMLNIA 124

Human   129 PPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSP 193
            |..||||.|||||||:|:||.||||||||||||||||:||||||||:||||||:|||||||||||
  Rat   125 PLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSP 189

Human   194 PAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRT 258
            |||||||||:||||||||||||||||||:||||||||||||.||.||.|||||||||||||||||
  Rat   190 PAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRT 254

Human   259 LESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
            |||||.||||||||:||||||||||||||.|:||||||||.|:|.||.|||||||||||||||||
  Rat   255 LESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHES 319

Human   324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCS 388
            ||||.||||||:||.||:||||||||||||||||:||.||||||||||:|.||||||||||||||
  Rat   320 TPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCS 384

Human   389 RENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLA 453
            |||||||||||||||||||||.||||||:|||||||||||||||||||||||||:|:||||||||
  Rat   385 RENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLA 449

Human   454 AQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHET 518
            .||||||||||||:||||||||||||||||.|||||:|.||||||||||||||.|||||||||||
  Rat   450 GQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHET 514

Human   519 YILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPS 583
            |||||||||.||..|.|:.|||||||||||:.:|.:|||||||||.|.|||||||||||||||||
  Rat   515 YILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQTFWFLYHKGHPPS 579

Human   584 EPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
            |||||||||||||||||||||||||||||||:||||:|.|||.|||.|
  Rat   580 EPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRPLLC 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		10/21 (48%)
		SapB	89..162	CDD:214797	58/72 (81%)
		MPP_ASMase	203..498	CDD:277321	264/294 (90%)
		ASMase_C	476..597	CDD:466022	103/120 (86%)
Smpd1	NP_001006998.1	SapB	85..158	CDD:214797	58/72 (81%)
		MPP_ASMase	199..494	CDD:277321	264/294 (90%)
		ASMase_C	472..593	CDD:466022	103/120 (86%)