DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMPD1 and SPOM_SPBC713.07C

DIOPT Version :10

Sequence 1:NP_000534.3 Gene:SMPD1 / 6609 HGNCID:11120 Length:631 Species:Homo sapiens
Sequence 2:NP_595346.1 Gene:SPOM_SPBC713.07C / 2541140 PomBaseID:SPBC713.07C Length:577 Species:Schizosaccharomyces pombe


Alignment Length:390 Identity:103/390 - (26%)
Similarity:161/390 - (41%) Gaps:72/390 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   197 GAP-VSRILFLTDLHWDHDYLEGTDPD--CAD--------PLCCRRGSGLPPASRPGAGYWGEYS 250
            |.| |.|.|.:||:|.|..|.:|:..|  |..        ||    |........||.||     
pombe    42 GKPLVGRFLHITDMHPDIYYEKGSTVDHYCHSYDHNSDDTPL----GKSKVGYLSPGPGY----- 97

Human   251 KCDLPLRTLESLLSGL-----GPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFL- 309
            :||.....::..|..|     ...|..|.:.||||...||..:...:.|...|.:...||.|.: 
pombe    98 ECDSSPALIDKTLEWLKEHQDDVLGGIDFILWTGDNSRHDNDNHFPRTQSEILASNEDLVNKMIE 162

Human   310 --GPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS 372
              ..||:..|:||::..|.|     .:|...||  :...:|.||:..:|.|...|...|.:|...
pombe   163 AFPDVPIVSAIGNNDIYPHN-----IMEAGPSS--MTRQLAGAWDALIPYEERHTFEKGSYYLCD 220

Human   373 PYPG-LRLISLNMNFCSRENFWL---LINSTDPAGQL--QWLVGELQAAEDRGDKVHIIGHIPP- 430
            ..|. |..||:|..:.|.:|..:   ..::.|..|.|  :|...:|:|...:|.||.::||||| 
pombe   221 VIPDKLAAISINTLYLSNKNAAVDGCPDDNLDEPGSLFMRWFKIQLEAYRLKGMKVWLLGHIPPT 285

Human   431 -GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGL- 493
             |...:....::..::..:.:.:..|.:||.:::.| ||.:.:.|          |..|...|: 
pombe   286 RGQWYEDCYTSFTDLLYEFRDIIVGQLYGHMNINHF-VFLEFDKL----------PVDTESYGIK 339

Human   494 --NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYG---LPNTLPT 553
              .|.|....||..|:       :..|:..|||:..:.|.:.::.|     .|.|   :|...||
pombe   340 SAQPKYVKSLIDAQYA-------ELPTFPENLTEEFLNGTVGNYSL-----ATVGGSIIPEMFPT 392

Human   554  553
            pombe   393  392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMPD1NP_000534.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
SapB 89..162 CDD:214797
MPP_ASMase 203..498 CDD:277321 84/323 (26%)
ASMase_C 476..597 CDD:466022 19/84 (23%)
SPOM_SPBC713.07CNP_595346.1 MPP_ASMase 49..338 CDD:277321 82/315 (26%)
Blue background indicates that the domain is not in the aligned region.

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