Protein Alignment SMPD1 and Smpd1

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_035551.1
• Gene: Smpd1 / 20597
• MGIID: 98325
• Length: 627
• Species: Mus musculus
• Alignment Length: 633
• Identity: 519/633 - (81%)
• Similarity: 556/633 - (87%)
• Gaps: 8/633 - (1%)

Human     1 MPRYGASLRQSCPRSGREQGQDGTAGAP--GLLWMGLVLALALALALALALSDSRVLWAPAEAHP 63
            ||.:.||..|...|:|.||..:.:..||  ||||||      |.|||.|||.||.|||.||.|:|
Mouse     1 MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWMG------LGLALVLALFDSTVLWVPARAYP 59

Human    64 LSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIA 128
            |..:||..:...|.|.|:..|||.|||||.||.||||:|.|||||||||||||||||:|.:|.||
Mouse    60 LPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIA 124

Human   129 PPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSP 193
            |..||||.|||||||:||||.||||||||||||||||:||||||||:||||||:|||||||||||
Mouse   125 PLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSP 189

Human   194 PAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRT 258
            |||||||||:||||||||||:|||||||.||||||||||||.||.|:.|||:|||||||||||||
Mouse   190 PAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRT 254

Human   259 LESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
            |||||.||||||||:||||||||||||||.|:||||||||||:|.||||||||||||||||||||
Mouse   255 LESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHES 319

Human   324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCS 388
            ||||.||||||:||.||:||||||||||||||||:||.||||||||||:|.||||||||||||||
Mouse   320 TPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCS 384

Human   389 RENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLA 453
            |||||||||||||||||||||.||||||:|||||||||||||||||||||||||:|:||||||||
Mouse   385 RENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLA 449

Human   454 AQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHET 518
            .||||||||||||:||||||||||||||||||||||:|.||||||||||||||.|||||||||||
Mouse   450 GQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHET 514

Human   519 YILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPS 583
            |||||||||..|..|.|:.|||||||||||:.:|.:|||||||||.|.|||||||||||||||||
Mouse   515 YILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPS 579

Human   584 EPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
            |||||||||||||||||||||||||||||||:||||:|..||.|||.|
Mouse   580 EPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDANRLWSRPLLC 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		9/21 (43%)
		SapB	89..162	CDD:214797	59/72 (82%)
		MPP_ASMase	203..498	CDD:277321	264/294 (90%)
		ASMase_C	476..597	CDD:466022	103/120 (86%)
Smpd1	NP_035551.1	SapB	85..158	CDD:214797	59/72 (82%)
		MPP_ASMase	199..494	CDD:277321	264/294 (90%)
		ASMase_C	472..593	CDD:466022	103/120 (86%)