Protein Alignment SMPD1 and asm-2

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_509894.2
• Gene: asm-2 / 181323
• WormBaseID: WBGene00000212
• Length: 618
• Species: Caenorhabditis elegans
• Alignment Length: 628
• Identity: 223/628 - (35%)
• Similarity: 336/628 - (53%)
• Gaps: 63/628 - (10%)

Human    30 LLWMGLVLALALALALALALSDSRVLWAPAEAHP----LSPQGHPARL----HRIV--------- 77
            :|.:|:||||       ::..:|.||..|.:.|.    .:.:|:.|.:    ::::
 Worm     7 ILGIGIVLAL-------VSNVESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINE 64

Human    78 PRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFED 142
            |..|      .::|..|......:...:.:......:.:..:.||:|..:..|.||::|::.|:|
 Worm    65 PENR------KMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKD 123

Human   143 DMVEVWRRSVLSPSEACGLLLGSTCGHWD--IFSSWNISLPTVPKPPPKP-PSPPAPGAPVSRIL 204
            ::|.|..|||.:|.|.||..: :.|||.|  :...|||::|. .|||.|| |..| ...|..::|
 Worm   124 EVVFVLERSVFTPEEICGAFI-ANCGHSDKPLTHMWNITIPG-GKPPIKPWPKIP-DNKPTFKVL 185

Human   205 FLTDLHWDHDYLEGTDPDC-------ADPLCCRRGS----GLP------PASRPGAGYWGEYSKC 252
            .|:|:|.||.|:.||:..|       ...:|||..|    |.|      |...| ||.||....|
 Worm   186 HLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVP-AGPWGMPYLC 249

Human   253 DLPLRTLESLLSGLGPA-GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYP 316
            |||.:|.||.:..:... ...|.:..|||..|||.|..|.......:..:|.:..::...||||.
 Worm   250 DLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNVFLEYFPGVPVYV 314

Human   317 AVGNHESTPVNSFPPPFIE--GNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRL 379
            ::||||..|.::..|..:.  .....:|||:.|::.|..|:|.|||.|::....||:.|.|||:|
 Worm   315 SIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDTVQYRASYAVYPKPGLKL 379

Human   380 ISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG--HCLKSWSWNYY 442
            ||||..:||..||:|.:|..||...|:||:.|||.:|::|:.||||.|||||  :|||.||||::
 Worm   380 ISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELVHIISHIPPGDNYCLKGWSWNFF 444

Human   443 RIVARYENTLAAQFFGHTHVDEFEVFYD-EETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNY 506
            .||.|||||:|..|:||||.|:|.|:|| ::...||....:::||.|||..|||.||:|:|||.|
 Worm   445 EIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFHFNWISPSLTTYDWLNPAYRIYEIDGGY 509

Human   507 SGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQT 571
            .|:::.|.|.:||..|:|:||:....|.|.|.|..||.|.:.:..|.:|.:|..::..:..||:.
 Worm   510 EGATYTVKDAKTYFANVTEANMKNKEPEWVLSYDTREHYQMADFSPQSWSDLSDKLWTNTTLFRD 574

Human   572 FWFLYHKGHPPSEPCGT--PCRLATLCAQLSARADSPALCRHL 612
            :..||::.|..:| |.|  .||...:|.....|:...:.|.||
 Worm   575 YVRLYYRNHYNNE-CYTDYKCRYTFVCDIKKGRSYDESFCDHL 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797	20/72 (28%)
		MPP_ASMase	203..498	CDD:277321	131/317 (41%)
		ASMase_C	476..597	CDD:466022	46/122 (38%)
asm-2	NP_509894.2	SapB	70..143	CDD:214797	20/72 (28%)
		MPP_ASMase	184..501	CDD:277321	131/317 (41%)
		ASMase_C	497..602	CDD:466022	39/105 (37%)