Protein Alignment SMPD1 and smpd1

DIOPT Version :10

• Sequence 1: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Sequence 2: XP_002943546.1
• Gene: smpd1 / 100487433
• XenbaseID: XB-GENE-997694
• Length: 582
• Species: Xenopus tropicalis
• Alignment Length: 564
• Identity: 350/564 - (62%)
• Similarity: 417/564 - (73%)
• Gaps: 12/564 - (2%)

Human    70 PARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQ 134
            |..||..:.:|...:||.||||||||.||.|:::.|:.:.|...|.|:|.::|..|::|.|:|||
 Frog    29 PPTLHSYLHQLGAGYGWRNLTCPICKVLFAALDISLEVDSNKEMVASLAERVCMALRLAEPSVCQ 93

Human   135 SIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAP 199
            ..:.||:.|::..|..|||.|||.||||:|:.||.|||.|:||||||..||||..||.||.||:|
 Frog    94 QTIQLFKKDIITAWVLSVLRPSEICGLLVGADCGVWDIGSNWNISLPNKPKPPVVPPVPPTPGSP 158

Human   200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPA-SRPGAGYWGEYSKCDLPLRTLESLL 263
            |||:|||||||||..||.|:...|.:|||||    :||| ::.||||||.||||||||.|:||||
 Frog   159 VSRVLFLTDLHWDRQYLPGSSASCQEPLCCR----MPPAHNQSGAGYWGTYSKCDLPLHTIESLL 219

Human   264 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNS 328
            ..:...||:..||||||||||:||.|||.|||.||.|:|.|:||:||.|||||||||||||||||
 Frog   220 RQVSAQGPYQAVYWTGDIPAHNVWQQTRADQLDALRTLTGLIRKYLGAVPVYPAVGNHESTPVNS 284

Human   329 FPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFW 393
            ||||:::||.||.|||.:||:.|..|||..||.|||..|||.:...|.|||:|||||||...|||
 Frog   285 FPPPYVQGNLSSHWLYHSMAQEWHHWLPQSALSTLRTAGFYTVPIGPRLRLVSLNMNFCDLGNFW 349

Human   394 LLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFG 458
            ||||.|||||||||||..||.||::|:|||||||||||.|||||||||||||.|||:|:||||||
 Frog   350 LLINYTDPAGQLQWLVEVLQEAEEKGEKVHIIGHIPPGLCLKSWSWNYYRIVNRYESTIAAQFFG 414

Human   459 HTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNL 523
            |||:||||:|||||||:||::|||::||.||:|.||||||||||||.|..|||:|||||||||||
 Frog   415 HTHLDEFEMFYDEETLTRPVSVAFISPSVTTFINLNPGYRVYQIDGEYPESSHMVLDHETYILNL 479

Human   524 TQANI-PGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCG 587
            |:||. ||..|.|.|||||.||||:.:..|..|..|..|...|.:||||||:|:|||| ..|.|.
 Frog   480 TEANARPGQDPRWTLLYRALETYGMKSAFPADWELLTRRFLQDERLFQTFWYLHHKGH-VDEVCQ 543

Human   588 TPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
            ..|:...|||..|.|:..|.||:.|:..|     :.||.|..||
 Frog   544 ENCKTTLLCALRSGRSSDPELCKDLLLPG-----KPLWERKQFC 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797	34/72 (47%)
		MPP_ASMase	203..498	CDD:277321	207/295 (70%)
		ASMase_C	476..597	CDD:466022	73/121 (60%)
smpd1	XP_002943546.1	SapB	48..121	CDD:214797	34/72 (47%)
		MPP_ASMase	162..454	CDD:277321	207/295 (70%)
		ASMase_C	432..554	CDD:466022	74/122 (61%)