Protein Alignment SMO and fz

DIOPT Version :9

• Sequence 1: NP_005622.1
• Gene: SMO / 6608
• HGNCID: 11119
• Length: 787
• Species: Homo sapiens
• Sequence 2: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 166/598 - (27%)
• Similarity: 262/598 - (43%)
• Gaps: 126/598 - (21%)

Human    39 PGPRSAGG-SARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGAT-STLLAGDSDSQEE 101
            |..||.|| .|.....:.|.|    |..|   |||:..::|..  :||..| ...|.|.: .|||
  Fly    28 PYYRSGGGLMASSGTELDGLP----HHNR---CEPITISICKN--IPYNMTIMPNLIGHT-KQEE 82

Human   102 AHGKLVLWSGL---RNAP----RCWAVIQPLLCAVYMPKCE-NDRVELPSRTLCQATRGPCAIVE 158
            |        ||   :.||    .|...:|..||::|:|.|. .:|...|.|:||::.|    :.|
  Fly    83 A--------GLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESAR----VCE 135

Human   159 R-----ERGWPDFLRCTPDRFP----------EGCTNEV-------------------------- 182
            :     ...||:.|.|:  :||          |..|:..
  Fly   136 KLMKTYNFNWPENLECS--KFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPH 198

Human   183 QNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLF 247
            :||.|....|.:.||......|...:|:..||..|....|.|.|...:..::.::.||.....||
  Fly   199 RNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLF 263

Human   248 TLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA--DGTMRLGE----- 305
            |:.||:.| .:..|||...:.::..|:.|....::|..  ||...:.||.  ...::||.
  Fly   264 TVLTFLID-SSRFRYPERAIVFLAVCYLVVGCAYVAGL--GAGDSVSCREPFPPPVKLGRLQMMS 325

Human   306 ---PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTT--YQPLSGKTSYFHLLTW 365
               ....:|.||.::|:.:|:..||...|:..|.:||   |.|.|..  ::.:..|:..|||:.|
  Fly   326 TITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAW---FLAAGLKWGHEAIENKSHLFHLVAW 387

Human   366 SLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIK 430
            ::|.:.|:::||:|:|:||.:||:||||..:......|::.|:.:.|.:|..||:.|.::||.|:
  Fly   388 AVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIR 452

Human   431 S--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT---FSCHFYDFFNQAEWERSF-RDY-- 487
            :  ...|    |...|:...|||:|.|..|   |:|..   ..|.||:::|..||...: ||.
  Fly   453 TVMKTDG----KRTDKLERLMLRIGFFSGL---FILPAVGLLGCLFYEYYNFDEWMIQWHRDICK 510

Human   488 ---VLCQANVTIGLPTKQPIPDC-EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRT 548
               :.|.|....|.|..:||... .:|...|:||           |:..|.|:::..|::.||..
  Fly   511 PFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLV-----------GVTSSVWLYSSKTMVSWRNF 564

Human   549 WCRLTGQSDDEPK 561
            ..||.|:   ||:
  Fly   565 VERLQGK---EPR 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	44/179 (25%)
		Frizzled	221..550	CDD:279827	101/352 (29%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	38/135 (28%)
		Frizzled	237..564	CDD:279827	101/350 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810