DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMO and Corin

DIOPT Version :9

Sequence 1:	NP_005622.1	Gene:	SMO / 6608	HGNCID:	11119	Length:	787	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	164	Identity:	44/164 - (26%)
Similarity:	65/164 - (39%)	Gaps:	32/164 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    68 AP--CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVY 130
            ||  |.|:....|.|..:||..|..........|.|....|..:..|.:. ||:.::...||.::
  Fly   775 APGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDV-RCYELVSLFLCTLF 838

Human   131 MPKC-ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDR-FP--EGCT--NEVQNIKF 187
            :||| ::.....|.:|||..|...|.......|  .|::|.|...: ||  |.|.  :||:.:
  Fly   839 VPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREV-- 901

Human   188 NSSGQCEVPLVRTDNPKSWYEDVEGC-GIQC-QN 219
                     :....:||        | |.|| ||
  Fly   902 ---------MRAATHPK--------CDGFQCDQN 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	36/137 (26%)
SMO	NP_005622.1	Frizzled	221..550	CDD:279827
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	32/116 (28%)
		LDLa	911..942	CDD:238060	5/8 (63%)
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900