Protein Alignment SMO and smo

DIOPT Version :10

• Sequence 1: NP_005622.1
• Gene: SMO / 6608
• HGNCID: 11119
• Length: 787
• Species: Homo sapiens
• Sequence 2: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 275/739 - (37%)
• Similarity: 420/739 - (56%)
• Gaps: 90/739 - (12%)

Human    10 PELPLL------GLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSH----- 63
            |.:|.:      .:|.|.::.|....:|..|:.|   |.||..|......:.|   .|::
  Fly     7 PRMPNIMMFLEVAILCLWVVADASASSAKFGSTT---PASAQQSDVELEPING---TLNYRLYAK 65

Human    64 ------------------CGRAAPCEPL--RYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVL 108
                              |.|.|.|.|.  ..|.|.||.|||..:|..|. |..:::|.:.||..
  Fly    66 KGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLT-DFHTEKELNDKLND 129

Human   109 WSGLRNAPRCWAVIQPLLCAVYMPKCE----NDRVELPSRTLCQATRGPCAIVERERGWPDFLRC 169
            :..|::.|:|||.|||.||||:.||||    .|.|.|||..:|:.|..||.|:.....:|.||||
  Fly   130 YYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC 194

Human   170 TPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYI 234
            ....||..|||..:.:|||.:|||..|||.||...|:|..:||||::|::||:|:.||:.:|..|
  Fly   195 NETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLI 259

Human   235 AAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADG 299
            ...|::..|..||.::||..||:|:|:|||||:||:|.||.:..:|||.||..|:|.:||||.||
  Fly   260 GWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDG 324

Human   300 TMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLT 364
            |:|..|||:.|.|||::|||:|||.|.||:||||.||||||  ::|:|.....:..|.|||||:.
  Fly   325 TLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH--WRAMGHVQDRIDKKGSYFHLVA 387

Human   365 WSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSI 429
            ||||.|||:..:|.::|||:|:.|||||||.|:..|||.:|.|:..|:::||||:.||::.||.:
  Fly   388 WSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGL 452

Human   430 KSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANV 494
            |.....:.|..|::||:..::|:|:...|...|:|:..:||..:|.:..||.:|||.:::|:.:.
  Fly   453 KHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISS 517

Human   495 TIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDE 559
            ..     :....|.|:||||:.|.:::|..:|.:||.||||.||.:::..|:|...:..|:...|
  Fly   518 VF-----EEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVE 577

Human   560 PKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSA----DVSSAWAQ 620
            ..::.|.|:||:.::||.: .::.|: ||.:::. :|..|| ||.||:|:.::    |:||.||.
  Fly   578 EVKMPKHKVIAQTWAKRKD-FEDKGR-LSITLYN-THTDPV-GLNFDVNDLNSSETNDISSTWAA 638

Human   621 HVTKMVARRGAI-----------------LPQDISVTPVATPVPPEEQANLWLVEAEISPELQ-- 666
            ::.:.|.||.|:                 |..:|||:  ...|..|.:.|  .|::::|.::.
  Fly   639 YLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVS--VRHVSVESRRN--SVDSQVSVKIAEM 699

Human   667 ----------KRLGRKKKRRKRKK 680
                      |..|....||.:::
  Fly   700 KTKVASRSRGKHGGSSSNRRTQRR 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	59/135 (44%)
		7tmF_SMO_homolog	220..550	CDD:320158	148/329 (45%)
		TM helix 1	229..254	CDD:320158	8/24 (33%)
		TM helix 2	264..285	CDD:320158	11/20 (55%)
		TM helix 3	315..341	CDD:320158	18/25 (72%)
		TM helix 4	359..375	CDD:320158	11/15 (73%)
		TM helix 5	397..426	CDD:320158	12/28 (43%)
		TM helix 6	448..475	CDD:320158	7/26 (27%)
		TM helix 7	511..536	CDD:320158	12/24 (50%)
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	59/135 (44%)
		7tmF_SMO_homolog	245..568	CDD:320158	148/329 (45%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	11/20 (55%)
		TM helix 3	340..366	CDD:320158	19/27 (70%)
		TM helix 4	382..398	CDD:320158	11/15 (73%)
		TM helix 5	420..449	CDD:320158	12/28 (43%)
		TM helix 6	471..498	CDD:320158	7/26 (27%)
		TM helix 7	529..554	CDD:320158	12/24 (50%)