DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMN2 and Smn

DIOPT Version :10

Sequence 1:XP_047273575.1 Gene:SMN2 / 6607 HGNCID:11118 Length:295 Species:Homo sapiens
Sequence 2:NP_524112.1 Gene:Smn / 39844 FlyBaseID:FBgn0036641 Length:226 Species:Drosophila melanogaster


Alignment Length:291 Identity:77/291 - (26%)
Similarity:120/291 - (41%) Gaps:94/291 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    28 SDDSD--IWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQ 90
            ||:::  :|||:.|:|.||::|...:.||               .:|.....||.:::|.||:.:
  Fly     2 SDETNAAVWDDSLLVKTYDESVGLAREAL---------------ARRLADSTNKREEENAAAAEE 51

Human    91 Q-----------------WKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNL 138
            :                 :||||...|.: .||..|...:.||:.::.|||:.|.||.|.:|..|
  Fly    52 EAGEISATGGATSPEPVSFKVGDYARATY-VDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLL 115

Human   139 SDLLSPICEVANNIEQ--NAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMP 201
            .||| |........||  .|:::|:| |:|..::    |.|:.|..  |||:..:..        
  Fly   116 VDLL-PSWGKRVRREQFLIAKKDEDE-QLSRPKA----SAGSHSKT--PKSSRRSRI-------- 164

Human   202 GPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADA----LGS 262
                                                ||..::||.||:.|..:...|.    ..:
  Fly   165 ------------------------------------SGGLVMPPMPPVPPMIVGQGDGAEQDFVA 193

Human   263 MLISWYMSGYHTGYYM-FPEASLKAEQMPAP 292
            ||.:||||||:||.|. ..|||..:.:...|
  Fly   194 MLTAWYMSGYYTGLYQGKKEASTTSGKKKTP 224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMN2XP_047273575.1 SMN 26..291 CDD:428716 76/288 (26%)
SmnNP_524112.1 SMN 2..215 CDD:428716 74/280 (26%)
Tudor_SMN 70..124 CDD:410469 23/55 (42%)

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