Protein Alignment SMN2 and smn1

DIOPT Version :10

• Sequence 1: XP_047273575.1
• Gene: SMN2 / 6607
• HGNCID: 11118
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_571266.1
• Gene: smn1 / 30432
• ZFINID: ZDB-GENE-990715-16
• Length: 281
• Species: Danio rerio
• Alignment Length: 276
• Identity: 145/276 - (52%)
• Similarity: 170/276 - (61%)
• Gaps: 32/276 - (11%)

Human    17 DSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQ 81
            :.|:|.|||||||||||||||||||||||||||||:|||..|............|||..|||||:
Zfish     6 EDVVFCRGTGQSDDSDIWDDTALIKAYDKAVASFKNALKGEDGATPQENDNPGKKRKNNKKNKSR 70

Human    82 KKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPIC 146
            |:..||..::|:|||.|.|.|||||.:|.|||.|:|.::.||||.||.|||.|||||||||:...
Zfish    71 KRCNAAPDKEWQVGDSCYAFWSEDGNLYTATITSVDQEKGTCVVFYTDYGNEEEQNLSDLLTEPP 135

Human   147 EVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPG 211
            ::..:..:.|...|.||  ||:||:.|.:| .||.:.|.||   .|..|..||...|..
Zfish   136 DMDEDALKTANVKETES--STEESDRSFTP-QKSGHAKHKS---KSNFPMGPPSWFPSF------ 188

Human   212 LKFNGPPPPPPPPPPHLLSC--------------WLPPFPSGPPIIPPPPPICPDSLDDADALGS 262
                  ||.|||||||....              |.|..|.|||:||||||:.||..:|.:||||
Zfish   189 ------PPGPPPPPPHFKKMDGRRGEGPGPSFPGWPPMIPLGPPMIPPPPPMSPDFGEDDEALGS 247

Human   263 MLISWYMSGYHTGYYM 278
            ||||||||||||||||
Zfish   248 MLISWYMSGYHTGYYM 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMN2	XP_047273575.1	SMN	26..291	CDD:428716	140/267 (52%)
smn1	NP_571266.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		9/13 (69%)
		SMN	15..281	CDD:428716	140/267 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..77		14/34 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..242		43/114 (38%)
		P2 (binding site for SNRPB). /evidence=ECO:0000250	225..252		18/26 (69%)
		Required for interaction with SYNCRIP. /evidence=ECO:0000250	264..279		145/276 (53%)