Protein Alignment SMN2 and smn-1

DIOPT Version :10

• Sequence 1: XP_047273575.1
• Gene: SMN2 / 6607
• HGNCID: 11118
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_001366985.1
• Gene: smn-1 / 172783
• WormBaseID: WBGene00004887
• Length: 207
• Species: Caenorhabditis elegans
• Alignment Length: 259
• Identity: 78/259 - (30%)
• Similarity: 107/259 - (41%)
• Gaps: 76/259 - (29%)

Human    25 TGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASL 89
            :|..:..|:||||.|||.||:   |.:...||    |||           ||....:.|.....:
 Worm     8 SGDMEVDDVWDDTELIKMYDE---SLQEISKN----ETS-----------AKITSRKFKGEDGKM 54

Human    90 QQWKVGDKCSAIWSEDGCI--YPATIASIDFKRETCV-VVYTGYGNREEQNLSDLLSPICEVANN 151
            ..||||.||.|.:.|:|.:  |||||.:|.......| |.:..||.:....:.||......:|:.
 Worm    55 YTWKVGGKCMAPYEENGEVTDYPATIDTIGGADNLEVGVTFIYYGGQAVVQMKDLWLNEEAIADA 119

Human   152 I--EQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKF 214
            :  |.:.|:.:..|.|::....||:|         ..|||..|.
 Worm   120 VKAENDLQKTKKTSTVNSVAHSNSKS---------TSSAPNTSM--------------------- 154

Human   215 NGPPPPPPPPPPHLLSCWLPPFPS-GPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYY 277
                                |||| .||:  ||..|....::..:|:.|||:||||||||||||
 Worm   155 --------------------PFPSFAPPV--PPNIIAMAPVNQKEAMNSMLMSWYMSGYHTGYY 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMN2	XP_047273575.1	SMN	26..291	CDD:428716	78/258 (30%)
smn-1	NP_001366985.1	SMN	9..199	CDD:428716	78/258 (30%)