Protein Alignment SMN1 and Smn

DIOPT Version :10

• Sequence 1: XP_047273571.1
• Gene: SMN1 / 6606
• HGNCID: 11117
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_524112.1
• Gene: Smn / 39844
• FlyBaseID: FBgn0036641
• Length: 226
• Species: Drosophila melanogaster
• Alignment Length: 291
• Identity: 77/291 - (26%)
• Similarity: 120/291 - (41%)
• Gaps: 94/291 - (32%)

Human    28 SDDSD--IWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQ 90
            ||:::  :|||:.|:|.||::|...:.||               .:|.....||.:::|.||:.:
  Fly     2 SDETNAAVWDDSLLVKTYDESVGLAREAL---------------ARRLADSTNKREEENAAAAEE 51

Human    91 Q-----------------WKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNL 138
            :                 :||||...|.: .||..|...:.||:.::.|||:.|.||.|.:|..|
  Fly    52 EAGEISATGGATSPEPVSFKVGDYARATY-VDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLL 115

Human   139 SDLLSPICEVANNIEQ--NAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMP 201
            .||| |........||  .|:::|:| |:|..::    |.|:.|..  |||:..:..
  Fly   116 VDLL-PSWGKRVRREQFLIAKKDEDE-QLSRPKA----SAGSHSKT--PKSSRRSRI-------- 164

Human   202 GPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADA----LGS 262
                                                ||..::||.||:.|..:...|.    ..:
  Fly   165 ------------------------------------SGGLVMPPMPPVPPMIVGQGDGAEQDFVA 193

Human   263 MLISWYMSGYHTGYYM-FPEASLKAEQMPAP 292
            ||.:||||||:||.|. ..|||..:.:...|
  Fly   194 MLTAWYMSGYYTGLYQGKKEASTTSGKKKTP 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMN1	XP_047273571.1	SMN	26..291	CDD:428716	76/288 (26%)
Smn	NP_524112.1	SMN	2..215	CDD:428716	74/280 (26%)
		Tudor_SMN	70..124	CDD:410469	23/55 (42%)