Protein Alignment SMN1 and smn1

DIOPT Version :10

• Sequence 1: XP_047273571.1
• Gene: SMN1 / 6606
• HGNCID: 11117
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_593088.1
• Gene: smn1 / 2542002
• PomBaseID: SPAC2G11.08C
• Length: 152
• Species: Schizosaccharomyces pombe
• Alignment Length: 260
• Identity: 45/260 - (17%)
• Similarity: 80/260 - (30%)
• Gaps: 120/260 - (46%)

Human    32 DIWDDTALIKAYDKAVASFK--HALK-NGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWK 93
            ::|||:.|..|::.|:..||  |::: .|.:.:            |..:...:|..:||..::
pombe     7 EVWDDSELRNAFETALHEFKKYHSIEAKGGVSD------------PDSRLDGEKLISAARTEE-- 57

Human    94 VGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQE 158
                 |....|:|                            ||.::.......|...:|:|.| :
pombe    58 -----SISKLEEG----------------------------EQMINQQTETTLEGDTHIQQFA-D 88

Human   159 NENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPP 223
            |:..|    ||...:|:.....:           |:..|||:.|
pombe    89 NKGLS----DEKPETRAAETHQE-----------FMEVPPPIRG--------------------- 117

Human   224 PPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMFPEASLKAEQ 288
                                          |...:....:::|||.:||:||   ..|...|:||
pombe   118 ------------------------------LTYDETYKKLIMSWYYAGYYTG---LAEGLAKSEQ 149

Human   289  288
            pombe   150  149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMN1	XP_047273571.1	SMN	26..291	CDD:428716	45/260 (17%)
smn1	NP_593088.1	SMN_N	4..35	CDD:439367	9/27 (33%)
		SMN_C	120..147	CDD:439368	8/29 (28%)