back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BOLL and sqd

DIOPT Version :10

Sequence 1:	XP_047301536.1	Gene:	BOLL / 66037	HGNCID:	14273	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_731825.1	Gene:	sqd / 41666	FlyBaseID:	FBgn0263396	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	1309	Identity:	234/1309 - (17%)
Similarity:	419/1309 - (32%)	Gaps:	446/1309 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   114 PPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDF-----QVEKKRIRPLETTQQIRKR 173
            ||...:..|...|...:|..:|..:..:..:..:|...::.     ..|::.:..|..:.|..:
  Fly   128 PPDPISNISFPNQQVEQKIHIADPVLIEASSKSWRQRRNELLGQMVAEERRNVEGLRESSQNGE- 191

Human   174 HCFGTEVHNLDAKVDSG--KTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKD 236
                        |:|..  :.|.|.|.|:::      ||....|         :||:|...:..|
  Fly   192 ------------KIDRALKRIVSLQSQLKQL------KPESIIS---------DSQKSLTNLNMD 229

Human   237 HTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMEL 301
            .....:...:.:...:                .|.|.:.|:.......|..|..|:       .|
  Fly   230 IDSDEEENDVVYLPES----------------QGGPFSNLAELKTHPAHLAVFINY-------LL 271

Human   302 LDGKNGKSCYFYHGVHKISDQHTLQTFQGMCK---AWDIEELVS-LGKKLKACPYYTARELIQDA 362
            |.| |..|.:||    .|:|.:  |:..|..|   .|..|...: :......|...:.:.:||..
  Fly   272 LHG-NPSSLFFY----LITDAY--QSAYGTAKEFRRWAFEIFSTFIIPNSPMCIPNSNQSVIQPI 329

Human   363 DIIFC---------------------------PYN-YL--------LDAQIRES----------- 380
            |.|.|                           ..| ||        |..|:.||
  Fly   330 DKIMCMTAEHIGDSDTDTLKRIFVPGRQRAVTDINMYLNDFRQKKQLGGQVSESTNQLTHMVRGD 394

Human   381 --MDLNLKEQVVI--LDEAHNIED---CARESASY-----SVTEVQL-------------RF--- 417
              |:..:.||::.  |::..|..|   |...:.|.     :|.::.|             :|
  Fly   395 MTMEHRVGEQMLFRCLEQCSNSTDFDSCEIRTQSIISSLATVIKIVLGKTSSSSNEKMLDKFPQF 459

Human   418 -ARD-------ELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIW------ 468
             |||       :|.:.:.|.|:.|.|.            ...|:...|...|:....||
  Fly   460 MARDKPPGKSRKLPANIKNRIQVKGHS------------FSINSVNTVHYCYQCRDAIWGMQPWI 512

Human   469 ---SGNEMLLTLH-KMGITTATFPILQGHFSAVLQK-EEKISPIYGKEEA-----------REVP 517
               |..::.:..| ...:|.|.:|:.|..     || :.::|.:.|:.:|           .|.|
  Fly   513 YFCSNCDVKVHPHCTSALTDACYPVTQSK-----QKSKSRLSGLIGRSDANDDEDSGSNARHEQP 572

Human   518 VISAST--------QIMLKGLFM---VLDYLFRQNSRFADDYKIAIQQ-------TYSW------ 558
            .:.:::        ..|.:||..   .:.|......:...:.|::|..       |.||
  Fly   573 NVKSTSSDSGIGGEHNMDRGLVSRSHSMRYRVATLPQSLSEDKVSIPSSKRDRSVTPSWQRSTGY 637

Human   559 ----TNQIDISD----KNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSG 615
                .::||.||    |:..|     ::||.:.::...::...::.|.:.|..:|.|
  Fly   638 DLTPADEIDESDIGDRKSKYL-----ERRSLESSSRMAIDLQSVSAASSCSHHSGSV-------- 689

Human   616 TLSPMKSFSSELGV--TFTIQLEANHIIKNSQIMSSKFIIYVVACARVSSLKNTETFEFQDEVGA 678
                  :...::.|  |.|:|.             |:|            :.....||.:.|...
  Fly   690 ------AMDDDICVRRTTTLQF-------------SRF------------MDGDSDFEIETEATP 723

Human   679 LLLSVCQTVSQGILCFL-PSYKLLEKLKERWLSTGLWH--NLELVKTVIVEPQGGEK-------- 732
            |.    |.:...::..| |..|..:::......|...|  ||:::..|..:|....|
  Fly   724 LE----QLIGWDVIRHLKPKEKKRQEVINELFHTERTHVRNLKILYHVFYKPIVTSKIVTEELAN 784

Human   733 ---TNFDELLQVY---YDAIKYKGEK---------------DGALLVAVCRGKVSEGLDFSDDNA 776
               .|.:|||.::   .||::.:.||               .|.|:.::..|:.:|.|      .
  Fly   785 LLFANLEELLNLHKSMSDAMRAEVEKWRSAPPRVNGGIYGDIGVLMESMFDGEAAENL------M 843

Human   777 RAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGA 841
            |...|.               .|:..|                    ||.....||.|.::|  |
  Fly   844 RVTATF---------------CQHQQH--------------------ALEFLRTRCKREKDD--A 871

Human   842 LILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEF-----------------SKKHQ 889
            .:.......:||......|...:..::|....:...||::|::                 :|:..
  Fly   872 FVRFLAEAESNPVCRKLQLKDMIPVEMQRLVKYPLLLETIAKYTTEPSEEQNCLLRTVASAKRIL 936

Human   890 KVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASH------LSPENFVEDEAKIC------ 942
            ..:|.:.::..|::    .||....:..|||:..|...|      |:....|.|....|
  Fly   937 SAVNTAKRNAENLR----RLEELQKRTDTSPFDKEFVGHDYTNLNLTKFRLVHDGPLTCRFNRGK 997

Human   943 VQELQCP------KIITKNSPLPSSII-----SRKEKNDPVF-LEEAGKAEKIVISRSTSPTFNK 995
            :.||...      .:.||||.....::     |::.:..|:. |......||....|:....||.
  Fly   998 MIELHVVLLENMLVLFTKNSDGNKLVLKALEPSKETRWSPILPLAPLIAKEKANDKRAFFLIFNS 1062

Human   996 Q-------------TKRVSWSSFNSLGQYFTGKIPKATPELGSSEN-SASSPPRFKTEKMESKTV 1046
            |             |:|.:|  |..:|.....:  |.....|...| ..|:.....::.:....|
  Fly  1063 QYGAQIYELVAGTATERKTW--FKLMGDQIMSE--KKNQAAGIDHNFDVSAQTTLDSDGVAKVNV 1123

Human  1047 LPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEAL---DPDIELSLV 1108
            :.......::.:|:        |..||:            .|::..|...|.|   |..|..:|:
  Fly  1124 VTHPRLVNANEITI--------QQPTIL------------EHAQPVLTPAEKLKRSDEIIIQTLI 1168

Human  1109 SEED--KQSTSNRDFETEAED-ESIYFTPEL-----YDPEDTDEEKNDLAETDRGNRLAN--NSD 1163
            :::.  .|..||.|.:...|: |.|  |..|     .|.:..|.::..::....||||.:  |..
  Fly  1169 TKQTILAQFLSNDDSKGNTEELEKI--TEVLGGLAVVDLKQRDGKELAMSAIVHGNRLLDSINQS 1231

Human  1164 CILAKDLFE 1172
            ..:.|::.|
  Fly  1232 LNIRKEMGE 1240

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.