DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMARCD2 and Bap60

DIOPT Version :9

Sequence 1:	NP_001091896.1	Gene:	SMARCD2 / 6603	HGNCID:	11107	Length:	531	Species:	Homo sapiens
Sequence 2:	NP_511143.2	Gene:	Bap60 / 32268	FlyBaseID:	FBgn0025463	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	305/557 - (54%)
Similarity:	366/557 - (65%)	Gaps:	91/557 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    15 SPGGGAVAAALGAPPPPAGPGMLPGPALRGPGPAGGVGGPGAAAFRPMG-PAGPAAQYQRPGMSP 78
            :||...|.:.. .||||| |||.|.|             |..|:|.|.| |           :.|
  Fly     6 APGQAPVQSRY-QPPPPA-PGMRPYP-------------PPGASFPPRGFP-----------LHP 44

Human    79 GNRMPMAGLQVGPPAGSPFGAAAPLRPGMP-PTMMDPFRKRLLVPQAQPPMPAQRRGL------- 135
            ....|:.|  ....||.|   ..|..||:| |:::....:       ||...:..||.
  Fly    45 NTTQPVPG--TANVAGVP---GVPGVPGVPGPSLLQRAAQ-------QPGFQSSLRGTGAGGGGV 97

Human   136 ----------------------------KRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQT 172
                                        |::|:|:|:|||::|:||||||||||||.||||||.|
  Fly    98 GSGGGSKRSNESRSLGGGGSKSDFATAKKKKKLAEKILPQKVRDLVPESQAYMDLLTFERKLDAT 162

Human   173 IARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKAEGDSAGTAGTPGGTPAGDKVASWELRVEGK 237
            |.|||::||||:|:|:.|||||||:|||||.||| |..:.|..|.         ||||||||||:
  Fly   163 IMRKRLDIQEALKRPMKQKRKLRIFISNTFYPSK-EPTNDGEEGA---------VASWELRVEGR 217

Human   238 LLDD-----PSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVK 297
            ||:|     .:|.|||||||||||||||||||||||||||||||..|||||||||||||||.||:
  Fly   218 LLEDGKGDPNTKIKRKFSSFFKSLVIELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGDRNVR 282

Human   298 CTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFRQI 362
            ||:||:||:||.|:|||||||||||||||||..|:.|||.|||.::|||.||||||||::|..||
  Fly   283 CTILLLLDYQPLQFKLDPRLARLLGVHTQTRPVIISALWQYIKTHKLQDAHEREYINCDKYLEQI 347

Human   363 FSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLAST 427
            |||.|::|:|||.:|..||..||||||||.|. ...:.|:||||||||||||.||.||::||.||
  Fly   348 FSCQRMKFAEIPQRLNPLLHPPDPIVINHFIE-SGAENKQTACYDIDVEVDDTLKNQMNSFLMST 411

Human   428 TNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTDPQDFIQEWLRSQRRDLKIITDVIGNPEEE 492
            .:||||..||.|||||:::|||:||.|:|.|||:.|||.||..|:.|:.||||::|||.||||||
  Fly   412 ASQQEIQGLDTKIHETVDTINQMKTNREFFLSFAKDPQMFIHRWIISETRDLKLMTDVAGNPEEE 476

Human   493 RRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIR 529
            |||.||:|||..|||.|:.|.||.|:|.||||.||||
  Fly   477 RRAEFYYQPWTHEAVSRYFFTKVNQKRAELEQALGIR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD2	NP_001091896.1	PHA03201	61..>148	CDD:165468	24/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..226		5/20 (25%)
		SWIB_BAF60B	307..386	CDD:349494	53/78 (68%)
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	51/75 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1605
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	629	1.000	Inparanoid score	I858
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55104
OrthoDB	1	1.010	-	-		D1027566at2759
OrthoFinder	1	1.000	-	-		FOG0000716
OrthoInspector	1	1.000	-	-		otm40795
orthoMCL	1	0.900	-	-		OOG6_100964
Panther	1	1.100	-	-	O	PTHR13844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	1	1.000	-	-		X681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870