Protein Alignment SMARCD1 and SNF12

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_014420.1
• Gene: SNF12 / 855757
• SGDID: S000005306
• Length: 566
• Species: Saccharomyces cerevisiae
• Alignment Length: 543
• Identity: 114/543 - (20%)
• Similarity: 198/543 - (36%)
• Gaps: 192/543 - (35%)

Human   117 QNRNHNAKK-------KKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKR 174
            |::.:||.:       ...:|.::|..:.||:||..::..|:..|::||..|..:.|.    :||
Yeast    38 QDKANNASQITPTVPHSHPSDMVIPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLH----MKR 98

Human   175 PIKQKRK-------------------LRIFISNTF--NPAKSDAEDGEGTV----ASWELRVEGR 214
            .:.|..:                   |||||||..  .|.:.|..:....:    |:|.:|:|||
Yeast    99 MVAQWERSKLSQEFLYPHLNFPNVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRIEGR 163

Human   215 LLEDSALSKYDATKQKRKFSSFFKSLVIEL--------------------------DKDL----- 248
            ||::  :...|..::  |||||.:|:|::.                          ||.|
Yeast   164 LLDN--VQANDPARE--KFSSFIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKKLNLNLP 224

Human   249 ---------------------------------------------YGPDNHLVEWHRTATTQETD 268
                                                         |.|:|.:          :.|
Yeast   225 LQFSLPNGDNSTTTNTDQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPV----------DFD 279

Human   269 GFQVKRPGDVNVRCTVLLMLDYQP--PQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDP 331
            |..:||.|..||.||:.::....|  |.....|:|..::|:.:.|....|.::::||..::|...
Yeast   280 GLDIKRVGSENVECTISILRKSSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYKYIHLNELLTN 344

Human   332 HEREF-----------------------------VICDKYLQQIFES-------QRMKFSEIPQR 360
            .|..|                             |..|..|..:..|       ..||.:::...
Yeast   345 DESAFENLMGNRNNHNSNTSTSKMLDAASSQVSIVKLDTQLITLLPSSLKESSPDTMKLTDLLSL 409

Human   361 LHAL-LMPPEPIIINHVISVDPNDQKKTACYD---IDVEVDDTLKTQMNSF----------LLST 411
            :::. |:|.:||.|::.:.||     |.:.|.   :|:||.|....:.|:.          |...
Yeast   410 INSTHLLPLQPIEIDYTVRVD-----KASTYGELVLDIEVPDVNALKFNNTQRESQIGAAELNEN 469

Human   412 ASQQE-----IATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVG 471
            |.:.|     ||..|.:|...:..:::...:..|....:.||...:|:.:.|....||.::...|
Yeast   470 ARELEQIKPKIALQDKEITSVLSNLHESNKRYRFFKKISEDPVKALNECIASTSNALKVLSGDEG 534

Human   472 -NPEEERRAEFYFQPWAQEAVCR 493
             |.:..|||.||.:   .||:.|
Yeast   535 YNEDMVRRANFYKE---NEAMLR 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		14/56 (25%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		91/464 (20%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		96/473 (20%)
		SWIB_BAF60A	294..370	CDD:349493	18/112 (16%)
SNF12	NP_014420.1	SWIB_like	310..415	CDD:349490	16/104 (15%)