Protein Alignment SMARCD1 and smarcd1

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_001004862.1
• Gene: smarcd1 / 448163
• XenbaseID: XB-GENE-491104
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 515
• Identity: 489/515 - (94%)
• Similarity: 500/515 - (97%)
• Gaps: 7/515 - (1%)

Human     1 MAARAGFQSVAPSGGAGASGGAGAAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLP 65
            ||||||||||.| ||:|:     |.||||| |||||.||||||||||:|||||||||||||||||
 Frog     1 MAARAGFQSVTP-GGSGS-----ATAALGP-GTPGPAVRMGPAPGQGMYRSPMPGAAYPRPGMLP 58

Human    66 GSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMAD 130
            |||||||||:||||||||:|:.|||:||||||||||||||||||||||||.|||||:||||||||
 Frog    59 GSRMTPQGPAMGPPGYGGSPAARPGMAQSGMDQSRKRPAPQQIQQVQQQAAQNRNHSAKKKKMAD 123

Human   131 KILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   124 KILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKS 188

Human   196 DAEDGEGTVASWELRVEGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHR 260
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
 Frog   189 DAEDGEGTVASWELRVEGRLLEDAALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHR 253

Human   261 TATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKT 325
            |.|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
 Frog   254 TPTTQETDGFQVKRPGDMNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKT 318

Human   326 HKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACY 390
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   319 HKLQDPHEREFIICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACY 383

Human   391 DIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDW 455
            ||||||||||||||||||||||||||||.||||||||||||||||.|||||||||||||||||||
 Frog   384 DIDVEVDDTLKTQMNSFLLSTASQQEIAALDNKIHETIETINQLKIQREFMLSFARDPQGFINDW 448

Human   456 LQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT 515
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   449 LQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		83/101 (82%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		115/123 (93%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		299/305 (98%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		328/334 (98%)
		SWIB_BAF60A	294..370	CDD:349493	74/75 (99%)
smarcd1	NP_001004862.1	PRK13875	<2..86	CDD:237537	72/90 (80%)
		SWIB_BAF60A	287..363	CDD:349493	74/75 (99%)