DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMARCD1 and Non2

DIOPT Version :9

Sequence 1:	NP_003067.3	Gene:	SMARCD1 / 6602	HGNCID:	11106	Length:	515	Species:	Homo sapiens
Sequence 2:	NP_647745.1	Gene:	Non2 / 38341	FlyBaseID:	FBgn0035370	Length:	244	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	51/272 - (18%)
Similarity:	85/272 - (31%)	Gaps:	112/272 - (41%)

- Green bases have known domain annotations that are detailed below.

Human    82 GGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQA 146
            |.:|...|.      |:|.    |.:    ::....:....|||||.:.|..||..:...|
  Fly    71 GKDPDADPD------DESE----PSE----EEDPSSSEEEAAKKKKQSPKKRPQPTKHKAP---- 117

Human   147 YMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRV 211
                                          |:|||       |.|...|..|...|:.:.:|
  Fly   118 ------------------------------KKKRK-------TLNADDSGTESDAGSDSDYE--- 142

Human   212 EGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPG 276
                     :.|..|.|:|.|.:.                        .|.:.:::.||
  Fly   143 ---------VVKKPAAKKKAKAAG------------------------GTGSGRKSTGF------ 168

Human   277 DVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDK 341
                           ...:.|.|.|:.|:|..:..|..:::.:|..||...|.||..::|.|||.
  Fly   169 ---------------TRAYNLSPELSALMGESSLPRHEVVKKVWAIIKERDLYDPKNKQFAICDD 218

Human   342 YLQQIFESQRMK 353
            .|.::.:.:|.:
  Fly   219 ELMKVMKIRRFR 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		5/20 (25%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269\|PubMed:12917342	43..167		15/84 (18%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269\|PubMed:12917342	168..474		36/186 (19%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		34/174 (20%)
		SWIB_BAF60A	294..370	CDD:349493	18/60 (30%)
Non2	NP_647745.1	DEK_C	7..57	CDD:285919
Non2	NP_647745.1	SWIB	170..242	CDD:280380	18/61 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840