Protein Alignment SMARCD1 and smarcd1

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_938172.1
• Gene: smarcd1 / 323115
• ZFINID: ZDB-GENE-030131-1835
• Length: 510
• Species: Danio rerio
• Alignment Length: 517
• Identity: 458/517 - (88%)
• Similarity: 471/517 - (91%)
• Gaps: 9/517 - (1%)

Human     1 MAARAGFQSVAPSGGAGASGGAGAAAALGPGGTPGPPV-RMGP-APGQGLYRSPMPGAAYPRPGM 63
            ||||:|||...|.||....|.....|..|||..||.|. |||| .|...:|||||||  ||||||
Zfish     1 MAARSGFQPSTPGGGGAPMGPGPPVAGAGPGMGPGTPSGRMGPGGPQNHMYRSPMPG--YPRPGM 63

Human    64 LPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKM 128
            .|.||||||||||||||||.:|..|||:..  ||.|||||||.|||||||   ||||.:||||||
Zfish    64 PPASRMTPQGPSMGPPGYGASPVSRPGMPV--MDPSRKRPAPNQIQQVQQ---QNRNQHAKKKKM 123

Human   129 ADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPA 193
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   124 ADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPA 188

Human   194 KSDAEDGEGTVASWELRVEGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEW 258
            |.|||||||||||||||||||||||:|:|||:|||||||||||||||||||||||||||||||||
Zfish   189 KPDAEDGEGTVASWELRVEGRLLEDTAVSKYEATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEW 253

Human   259 HRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYI 323
            ||||||||||||||||||||.|||||||||||||||:|||||||||||||||||||||||||||:
Zfish   254 HRTATTQETDGFQVKRPGDVGVRCTVLLMLDYQPPQYKLDPRLARLLGIHTQTRPVIIQALWQYV 318

Human   324 KTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTA 388
            |||||||||||||:.||||||||||:|||||||||||||||||||||||||||||||||||||||
Zfish   319 KTHKLQDPHEREFINCDKYLQQIFETQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTA 383

Human   389 CYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFIN 453
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Zfish   384 CYDIDVEVDDTLKTQMNSFLLSTASQQEIAGLDNKIHETIETINQLKTQREFMLSFARDPQGFIN 448

Human   454 DWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT 515
            |||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Zfish   449 DWLQSQCRDLKTMTDVVGNPEEERRAEFYYQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		62/103 (60%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		98/123 (80%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		294/305 (96%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		322/334 (96%)
		SWIB_BAF60A	294..370	CDD:349493	70/75 (93%)
smarcd1	NP_938172.1	SWIB_BAF60A	289..365	CDD:349493	70/75 (93%)