Protein Alignment SMARCD1 and Bap60

DIOPT Version :9

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_511143.2
• Gene: Bap60 / 32268
• FlyBaseID: FBgn0025463
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 340/533 - (63%)
• Similarity: 382/533 - (71%)
• Gaps: 73/533 - (13%)

Human    30 PGGTP------GPPVRMGPAPGQGLYRSPMPGAAYPRPG--MLPGSRMTPQGPS--MGPPGYGGN 84
            ||..|      .||    ||||...|  |.|||::|..|  :.|.:.....|.:  .|.||..|.
  Fly     7 PGQAPVQSRYQPPP----PAPGMRPY--PPPGASFPPRGFPLHPNTTQPVPGTANVAGVPGVPGV 65

Human    85 PSVRPGLAQSGMDQSRKRPAPQQIQQVQQQ--------------------AVQNRNHNA------ 123
            |.|               |.|..:|:..||                    ....|::.:
  Fly    66 PGV---------------PGPSLLQRAAQQPGFQSSLRGTGAGGGGVGSGGGSKRSNESRSLGGG 115

Human   124 ----------KKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQ 178
                      ||||:|:|||||::|:||||||||||||.||||||.||||||||||||||||:||
  Fly   116 GSKSDFATAKKKKKLAEKILPQKVRDLVPESQAYMDLLTFERKLDATIMRKRLDIQEALKRPMKQ 180

Human   179 KRKLRIFISNTFNPAKSDAEDG-EGTVASWELRVEGRLLEDSALSKYDA-TKQKRKFSSFFKSLV 241
            ||||||||||||.|:|....|| ||.|||||||||||||||   .|.|. ||.||||||||||||
  Fly   181 KRKLRIFISNTFYPSKEPTNDGEEGAVASWELRVEGRLLED---GKGDPNTKIKRKFSSFFKSLV 242

Human   242 IELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLG 306
            |||||:||||||||||||||.|||||||||||||||.|||||:||:|||||.|||||||||||||
  Fly   243 IELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGDRNVRCTILLLLDYQPLQFKLDPRLARLLG 307

Human   307 IHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPI 371
            :|||||||||.|||||||||||||.||||::.|||||:|||..|||||:||||||:.||.||:||
  Fly   308 VHTQTRPVIISALWQYIKTHKLQDAHEREYINCDKYLEQIFSCQRMKFAEIPQRLNPLLHPPDPI 372

Human   372 IINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKT 436
            :|||.|. ...:.|:|||||||||||||||.||||||:||||||||..||.|||||::||||:||
  Fly   373 VINHFIE-SGAENKQTACYDIDVEVDDTLKNQMNSFLMSTASQQEIQGLDTKIHETVDTINQMKT 436

Human   437 QREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQ 501
            .|||.||||:|||.||:.|:.|:.||||.||||.||||||||||||:|||..|||.|||::||.|
  Fly   437 NREFFLSFAKDPQMFIHRWIISETRDLKLMTDVAGNPEEERRAEFYYQPWTHEAVSRYFFTKVNQ 501

Human   502 RRQELEQALGIRN 514
            :|.||||||||||
  Fly   502 KRAELEQALGIRN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		24/82 (29%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		59/163 (36%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		240/307 (78%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		262/337 (78%)
		SWIB_BAF60A	294..370	CDD:349493	62/75 (83%)
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	62/75 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146917
Domainoid	1	1.000	286	1.000	Domainoid score	I1605
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20670
Inparanoid	1	1.050	629	1.000	Inparanoid score	I858
Isobase	1	0.950	-	0	Normalized mean entropy	S1727
OMA	1	1.010	-	-		QHG55104
OrthoDB	1	1.010	-	-		D1027566at2759
OrthoFinder	1	1.000	-	-		FOG0000716
OrthoInspector	1	1.000	-	-		otm40795
orthoMCL	1	0.900	-	-		OOG6_100964
Panther	1	1.100	-	-	LDO	PTHR13844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	1	1.000	-	-		X681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750