Protein Alignment SMARCD1 and ssr3

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_593110.1
• Gene: ssr3 / 2541438
• PomBaseID: SPAC23G3.10C
• Length: 425
• Species: Schizosaccharomyces pombe
• Alignment Length: 418
• Identity: 145/418 - (34%)
• Similarity: 234/418 - (55%)
• Gaps: 33/418 - (7%)

Human   110 QVQQQAVQNRN-HNAKKKK---MADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQE 170
            ::.:..||:.| .:|:.||   :.::.:|..:.|.:||::.|:.|...|||||..|:|||.|:|:
pombe     6 RLPENGVQSGNGEDAELKKSMRIIEREIPDSLLEKIPEAEDYIALQDLERKLDSLIVRKRFDLQD 70

Human   171 ALKRPIKQKRKLRIFISNT-----FNPAKSDAEDGEGTVAS-----WELRVEGRLL-----EDSA 220
            :|.|...:.|.||::|.:|     :.....:.|:..|.:.|     |.|.:|||||     ||
pombe    71 SLSRNSHKTRILRMYIHSTVANQSWQQKGENQENNSGDINSLPIPEWTLHIEGRLLVNPDDED-- 133

Human   221 LSKYDATKQKRKFSSFFKSLVIEL--DKDLYGPDNHLVEWHRTATTQET-DGFQVKRPGDVNVRC 282
                |...:...|::||:.:.|::  ..||| |..:.|||::......| :|..|.|.||.:|..
pombe   134 ----DKAFELAPFTNFFRKIAIQILRSDDLY-PSGNYVEWNKLPDNSNTSNGITVTRKGDQSVDV 193

Human   283 TVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIF 347
            .::|..:..|.::||....|.:|||...|||.|:..||||||.|:|||..|:..:.|||.|:.:|
pombe   194 KIMLYPEEHPERYKLSKAFANILGIREGTRPDIVSYLWQYIKFHRLQDMEEKRLINCDKALRDLF 258

Human   348 ESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTA 412
            |:.|:.|..||:.::..|.|.:||:|.:.|:|..:..:|...:||.:..:|...:|:.|||.:..
pombe   259 EADRLYFPRIPELMNRFLEPIDPIVIPYTINVSEHTVEKVTIFDIRINTEDPRHSQIRSFLATMM 323

Human   413 SQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVG-NPEEE 476
            ||.:|.::|:|:.|.|:.|...:::.:||..|:..|..|||:|::||.|||:.:.|... |..|:
pombe   324 SQDKIRSIDDKLTELIQAITYSQSKYDFMKKFSESPIEFINEWIESQSRDLEIVLDGTNMNYAEK 388

Human   477 RRAEFYFQPWAQEAVCRY---FYSKVQQ 501
            |.|::|.|||..|:...|   ..||.||
pombe   389 RSADYYQQPWVHESAFHYLNLLNSKKQQ 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		21/60 (35%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		110/324 (34%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		120/344 (35%)
		SWIB_BAF60A	294..370	CDD:349493	33/75 (44%)
ssr3	NP_593110.1	SWIB	204..276	CDD:460488	31/71 (44%)