Protein Alignment SMARCD1 and ham-3

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_499250.1
• Gene: ham-3 / 176426
• WormBaseID: WBGene00044072
• Length: 446
• Species: Caenorhabditis elegans
• Alignment Length: 451
• Identity: 242/451 - (53%)
• Similarity: 310/451 - (68%)
• Gaps: 22/451 - (4%)

Human    71 PQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRP--APQQIQQVQQQAVQNRNHNAKKKKMADKIL 133
            ||||....|               ...|..:||  ||...|..|.|..:......|||:.|||::
 Worm    10 PQGPRFNHP---------------ATPQQVRRPINAPLPGQTAQIQGNRGPQPPKKKKRYADKLI 59

Human   134 PQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAE 198
            ..::|||||||||||||||||:|||.||.||::|:|||||||.|.|::|||:||:||...|...:
 Worm    60 QPKVRELVPESQAYMDLLAFEQKLDSTITRKKIDVQEALKRPQKIKKRLRIYISHTFIAGKEPEK 124

Human   199 DG-EGTVASWELRVEGRLLEDSALSKYDATKQ---KRKFSSFFKSLVIELDKDLYGPDNHLVEWH 259
            :| :.:|..||||||||||:|.......|..:   ||||||||||||||||||:|||||||||||
 Worm   125 EGDDASVPMWELRVEGRLLDDMQHPTVGANPRPAPKRKFSSFFKSLVIELDKDIYGPDNHLVEWH 189

Human   260 RTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIK 324
            ||..|.||||||||||||..|:||:||:|||||.:|||.||||::|||..:|||.||:|||||||
 Worm   190 RTPQTNETDGFQVKRPGDRPVKCTILLLLDYQPMKFKLHPRLAKVLGIAAETRPRIIEALWQYIK 254

Human   325 THKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKT-A 388
            |||||||.:|:.:..|.:|:|.|...:|:|.|||||||.||..|:|:::||:|....:.|.|| |
 Worm   255 THKLQDPQDRDTINNDLFLEQCFGVSKMRFMEIPQRLHQLLQQPDPLVLNHIIQRPDDGQDKTSA 319

Human   389 CYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFIN 453
            |||||||::|.:|.||.:|:.:..:..:|..||.||.:.::.||::|.:|:|.|.|:.:|.|||.
 Worm   320 CYDIDVELEDPVKQQMANFVHNQTNANDIQLLDQKIFDLVDQINEMKLRRDFFLRFSNEPSGFIK 384

Human   454 DWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRN 514
            .|:.||..||||:|:..|:.|.:|.|..|......|.|.||.|.|:||:|.||||:|||||
 Worm   385 KWVVSQNSDLKTLTESSGDGESDRYATTYSTTDTDEGVSRYMYQKIQQKRAELEQSLGIRN 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		6/31 (19%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		43/97 (44%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		176/310 (57%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		189/340 (56%)
		SWIB_BAF60A	294..370	CDD:349493	46/75 (61%)
ham-3	NP_499250.1	SWIB-MDM2	224..300	CDD:476812	46/75 (61%)