Protein Alignment SMARCD1 and swsn-2.2

DIOPT Version :10

• Sequence 1: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_491329.2
• Gene: swsn-2.2 / 172018
• WormBaseID: WBGene00015971
• Length: 449
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 233/476 - (48%)
• Similarity: 301/476 - (63%)
• Gaps: 39/476 - (8%)

Human    44 PGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQI 108
            |...:.|.|     |..||..|..| .|.|.:..||...|...|.|..|          |.|
 Worm     7 PNPQMNRHP-----YGTPGSAPQMR-RPGGFAGQPPQMHGPRMVAPPAA----------PLP--- 52

Human   109 QQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALK 173
                           ||||.|||.:..:||||.|:::.||.|||.|:|||.|:.||:||||||||
 Worm    53 ---------------KKKKYADKCIHPKIRELEPDAENYMALLASEQKLDSTLSRKKLDIQEALK 102

Human   174 RPIKQKRKLRIFISNTFNPAKSDAED-GEGTVASWELRVEGRLLEDSALSKYDATKQ---KRKFS 234
            ||.|.|::|||:||:||...|...:| .|.::..||||||||||::...:.....::   |||||
 Worm   103 RPSKVKKRLRIYISHTFIEEKQPEKDTDEASLPMWELRVEGRLLDEQPPAPAIPGQRPVPKRKFS 167

Human   235 SFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDP 299
            ||||||||||||::||||.||||||||..|.|||||||||.||..|:|.:||:||..|.:|||.|
 Worm   168 SFFKSLVIELDKEMYGPDQHLVEWHRTPQTNETDGFQVKRAGDRPVKCRILLLLDNHPAKFKLHP 232

Human   300 RLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHAL 364
            |||::|||.|:|||.||:|||||||||.||||.||:.:.||.:|.|.|...||:|.|:|.:||.|
 Worm   233 RLAKVLGIATETRPKIIEALWQYIKTHGLQDPQERDIINCDTFLSQCFGVNRMRFMEVPNKLHQL 297

Human   365 LMPPEPIIINHVISVDPNDQKK-TACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETI 428
            |...:|:..||:|......|:: :.|||||||::|.:|..|::|:.|.....:|.|||.|.::.|
 Worm   298 LQQTDPLEFNHIIQRPKEGQEQVSTCYDIDVEMEDPVKQFMHTFVHSPGLANDIQTLDQKCYDII 362

Human   429 ETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCR 493
            |.||:|||:|:|...|..:|..||..|:.||..|||||.::.|:.|.||.||.|.:|..:|.|.|
 Worm   363 EQINELKTRRDFYARFYTEPAEFIKSWVMSQNSDLKTMNELSGDLEAERFAESYVRPETEEGVQR 427

Human   494 YFYSKVQQRRQELEQALGIRN 514
            |.:.||.|:|.||||:||:|:
 Worm   428 YMFQKVNQKRHELEQSLGVRS 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		16/58 (28%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		42/122 (34%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		167/310 (54%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		179/340 (53%)
		SWIB_BAF60A	294..370	CDD:349493	45/75 (60%)
swsn-2.2	NP_491329.2	SWIB-MDM2	227..303	CDD:476812	45/75 (60%)