Protein Alignment SMARCC2 and SWI3

DIOPT Version :10

• Sequence 1: NP_001317217.1
• Gene: SMARCC2 / 6601
• HGNCID: 11105
• Length: 1245
• Species: Homo sapiens
• Sequence 2: NP_012359.1
• Gene: SWI3 / 853264
• SGDID: S000003712
• Length: 825
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 220/936 - (23%)
• Similarity: 354/936 - (37%)
• Gaps: 361/936 - (38%)

Human   242 ILDTDTFNEWMNEEDYEVNDDKN-PVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSP 305
            :.:|||..|...::|..:.|:.. |.:|..:..|.|:|                        ...
Yeast    37 VANTDTAGEESQQQDESLKDEATVPNTRDAESEAITVT------------------------AKQ 77

Human   306 SPTPEAKKKNAKKGPSTPYTKSKR--GHREEEQEDL---------TKDMDEPS------------ 347
            .||.:|.|.::::.|||..::::.  |...|:.::|         ..:.:.||
Yeast    78 QPTMQANKLDSQETPSTEESRAQNVFGQDNEDSDNLFGETESSVSNNEANTPSIPTNPVDNENNK 142

Human   348 --------------PVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDED-- 396
                          .|.|:|:|.:.|....:.::....||..:..|.:.:|.:.:|...:|:|
Yeast   143 PAIKEDSTIQDSNGDVKNMEDVKIQKEEEPENNTVIEGVKEESQPDENTKEMDEVEEDDEDDDQP 207

Human   397 ----ENS----TGNKGEQTKN-----------PDLH---EDNVTEQT------------------ 421
                :||    |.::.:|..|           ||.|   ::::.|:|
Yeast   208 MISPDNSIFGDTKSESKQLGNTSSVANTPSEIPDAHKAEQEDIIEKTESVDKKVDSGEERNEQER 272

Human   422 ------------------------------HHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKS 456
                                          |.|:||||:.||:...:|:||.::|||||..:..|
Yeast   273 EIMNDHSKSANPKKTTITRVEPETFEIPQAHEIVIPSYSKWFNLEKIHSIEVQSLPEFFTNRIPS 337

Human   457 KTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPT 521
            ||||:|:.|||||:::|||||.||.:.|..|||::||..|:.|:|.||.:|||||||||::..|.
Yeast   338 KTPEVYMRYRNFMVNSYRLNPNEYFSVTTARRNVSGDAAALFRLHKFLTKWGLINYQVDSKLLPK 402

Human   522 PMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKELDDLVPETAKGKPELQTSAS 586
            .:.||.||.:....|.|.||.|.:...|..:                  :|:.||.|..:.||.|
Yeast   403 NIEPPLTSQYSTRHDAPRGLFPFESYKPSVQ------------------LPDMAKLKKMMNTSDS 449

Human   587 QQML-NFPDKGKEK---------PTDMQNFGLRTDMYTKKNVP---------------------- 619
            :..| .:..:.|.|         .||.:| |.:.|...|.|..
Yeast   450 ESTLYKYLKESKRKYDEITHPPSTTDDEN-GDKNDNGGKMNNEVSTSTSMTGDANLLEEGETSRP 513

Human   620 -SKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYL--- 680
             .|.|........|::::...||:.::.:..||.||:::||:::.::|||.||:|||||.:|
Yeast   514 LKKVKILEQIDENWSKEDLQKLLKGIQEFGADWYKVAKNVGNKSPEQCILRFLQLPIEDKFLYGD 578

Human   681 ----EDSEASLGPLAYQP-IPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPT 740
                .|::..||||.|.| :|||:|.|||:||:|||..:|:|:...:..:.|::....:|
Yeast   579 GNGKGDNDNGLGPLKYAPHLPFSKSENPVLSTIAFLVGLVNPKTVQSMTQRAIQSAESIK----- 638

Human   741 ALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATDEKKEPKE 805
                                                                             
Yeast   639 ----------------------------------------------------------------- 638

Human   806 PREGGGAIEEEAKEKTSEAPKKDEEKGKEGDSEKESEKSDGDPIVDPEKEKEPKEGQEEVLKEVV 870
                                           |:|| |.||..||      :..|||.|
Yeast   639 -------------------------------SQKE-EISDQKPI------EHIKEGSE------- 658

Human   871 ESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLR 935
                                    .|:::...::...|..|||::..|...|:..||:||:.||.
Yeast   659 ------------------------IAISSLGYRSHIFATNEERQMNFLTNELIRLQMEKLDAKLN 699

Human   936 HFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYA------------------------EMR 976
            |.::||..|:.||:.||.|::.||..|..|:....|..                        |:|
Yeast   700 HLKKLEKFMELERKTLERQQENLLIQRLNFNQNSSKIVNVLSKCLNLISDSNINNSSVAEKEEIR 764

Human   977 ARQQHFQQMHQQQQQPPPALPPGSQP 1002
            ::..||:.|..:    |..|..|..|
Yeast   765 SQIDHFKSMLSK----PETLSIGKNP 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC2	NP_001317217.1	SWIRM-assoc_2	4..420	CDD:465143	43/239 (18%)
		RSC8	379..>739	CDD:227584	142/472 (30%)
		SWIRM-assoc_3	715..781	CDD:465145	4/65 (6%)
		PTZ00121	<721..978	CDD:173412	43/280 (15%)
		SWIRM-assoc_1	<911..977	CDD:465142	26/89 (29%)
		PHA03247	<999..1234	CDD:223021	2/4 (50%)
SWI3	NP_012359.1	RSC8	253..825	CDD:227584	176/696 (25%)