Protein Alignment SMARCC2 and smarcc2

DIOPT Version :10

• Sequence 1: NP_001317217.1
• Gene: SMARCC2 / 6601
• HGNCID: 11105
• Length: 1245
• Species: Homo sapiens
• Sequence 2: XP_021330286.1
• Gene: smarcc2 / 567476
• ZFINID: ZDB-GENE-100728-1
• Length: 1036
• Species: Danio rerio
• Alignment Length: 1097
• Identity: 816/1097 - (74%)
• Similarity: 901/1097 - (82%)
• Gaps: 69/1097 - (6%)

Human     1 MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFG 65
            ||||||||||||||:||:|||:||||||:||||||||||||||||||||||||||||||||||||
Zfish     1 MAVRKKDGGPNVKYFEASDTVSQFDNVRVWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFG 65

Human    66 KHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKS 130
            :||||.||||||:||||||||||:|||||||||||||||||||:|||||||||||||||||||||
Zfish    66 RHVSNPPLTKLPVKCFLDFKAGGALCHILAAAYKFKSDQGWRRFDFQNPSRMDRNVEMFMTIEKS 130

Human   131 LVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNNASHVVYPVPGNLEEEEWVRPVM 195
            ||||||||||.|:|..|||||||||||||||||||:|||||.::||||.|:|.:||:||||||||
Zfish   131 LVQNNCLSRPVIYLSSEIEPKLLGKLKDIIKRHQGSVTEDKLSSSHVVVPIPASLEDEEWVRPVM 195

Human   196 KRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVN 260
            |||||:||||||:||||||||.|||:||:|||.|..|||||||||||||.|.||||||||||||.
Zfish   196 KRDKQMLLHWGYWPDSYDTWISASEVEAAVEDPPAAEKPRKVHAKWILDLDQFNEWMNEEDYEVG 260

Human   261 DDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTP---EAKKKNAKKGPST 322
            :. .|  |||:||||||||||::|| :|||||....|||||||||||||   |:||||.||||:|
Zfish   261 EG-GP--RRKRISAKTLTDEVSAPD-ERRDKKPSGAKKRKRSPSPSPTPPPQESKKKNTKKGPTT 321

Human   323 PYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDES 387
            ||||||||.||||||||||::|||||||.|||.|||||| |||||:|.|||||||||||||||||
Zfish   322 PYTKSKRGQREEEQEDLTKELDEPSPVPAVEEATLPKTV-TKKDSDSTPVKGGTMTDLDEQEDES 385

Human   388 METTGKDEDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNG 452
            |||.||:|:|.|...|||..|..||||||||||||||||||||||||||||||||||||||||||
Zfish   386 METVGKEEEEGSPSVKGEPVKGSDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNG 450

Human   453 KNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAE 517
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Zfish   451 KNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDSE 515

Human   518 SRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKELDDLVPETAKGKPELQ 582
            ||||||||||||||||||||||.|||||||..                                |
Zfish   516 SRPTPMGPPPTSHFHVLADTPSSLVPLQPKAS--------------------------------Q 548

Human   583 TSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMY 647
            ||:|||||:||:|.|:||.|:||||||||:|:||:.|:|:|.|||||||||:||||||||.||||
Zfish   549 TSSSQQMLSFPEKVKDKPADLQNFGLRTDVYSKKSGPAKNKNAASATREWTDQETLLLLEGLEMY 613

Human   648 KDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLA 712
            ||||||||||||||||||||||||||||||||||||.||||||||||:||||:||||||||||||
Zfish   614 KDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSSASLGPLAYQPVPFSQAGNPVMSTVAFLA 678

Human   713 SVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGT--- 774
            ||||||||||||||||||||:||||||.||||||||:|||||:.:|:.||.:|||.||||||
Zfish   679 SVVDPRVASAAAKSALEEFSRMKEEVPAALVEAHVRRVEEAARASGRQDPLYGLEGSGIAGTGLE 743

Human   775 TSDEPERIEESGNDEARVEGQATDEKKEPKEPREGGGAIEEEAKEKTSEAPKKDEEKGKEGDSEK 839
            .||:|.  ::.|.:....|||.:.||::.||.::  ||.|||  ||..|..||:||:.:|.::|:
Zfish   744 DSDKPS--DDGGEENKSSEGQPSQEKRDSKESKD--GASEEE--EKQGENGKKEEERAREVETER 802

Human   840 ESEKSDGDPIVDPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKA 904
            |:||:|.: :.|.|||||.|||.||..:: .|:|||:|.|||||:|||||:||||:|||||||||
Zfish   803 ETEKTDSE-MADGEKEKERKEGSEEAQRD-GETEGEKKAKVERDVGEGNLATAAASALAAAAVKA 865

Human   905 KHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQ 969
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
Zfish   866 KHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQSFHMEQ 930

Human   970 LKYAEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPTGAAGPPAVHGLAVAPASVVPAPAGSGAP 1034
            |||||||||||||||:..|..    :..||||     .|..||..| ..||.|| .|.|..|.||
Zfish   931 LKYAEMRARQQHFQQIQHQHH----SNQPGSQ-----SATAPPVPH-QPVATAS-APPPTPSPAP 984

Human  1035 PGSLGP-SEQIGQAGSTAGPQQQQPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPS 1090
            ..:... ||......:.:.|.....|||....:..|..      |.|.:|....|||
Zfish   985 LTATNTHSEAPPPPAAHSSPPNNTQAGAAHDSSTTPLA------GDSLYPTAPVPPS 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC2	NP_001317217.1	SWIRM-assoc_2	4..420	CDD:465143	345/418 (83%)
		RSC8	379..>739	CDD:227584	292/359 (81%)
		SWIRM-assoc_3	715..781	CDD:465145	52/68 (76%)
		PTZ00121	<721..978	CDD:173412	182/259 (70%)
		SWIRM-assoc_1	<911..977	CDD:465142	64/65 (98%)
		PHA03247	<999..1234	CDD:223021	29/93 (31%)
smarcc2	XP_021330286.1	SWIRM-assoc_2	4..418	CDD:465143	345/418 (83%)
		RSC8	380..>726	CDD:227584	305/377 (81%)
		PTZ00121	<754..>935	CDD:173412	131/186 (70%)
		SWIRM-assoc_1	<872..938	CDD:465142	64/65 (98%)