Protein Alignment SMARCC2 and mor

DIOPT Version :10

• Sequence 1: NP_001317217.1
• Gene: SMARCC2 / 6601
• HGNCID: 11105
• Length: 1245
• Species: Homo sapiens
• Sequence 2: NP_524373.1
• Gene: mor / 41942
• FlyBaseID: FBgn0002783
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 1294
• Identity: 568/1294 - (43%)
• Similarity: 746/1294 - (57%)
• Gaps: 262/1294 - (20%)

Human     5 KKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYI--QAEPPTNKSLSSLVVQLLQFQEEVFGKH 67
            ||||.||:.::::.:|:..|:::|.||.||.|||:  .:||.|.:||:.|::..||:.|...||:
  Fly     7 KKDGSPNIDFFQSPETLQGFESIRQWLQKNCKKYLAHSSEPITKESLAQLLIHFLQYVEAKLGKN 71

Human    68 VSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDF---QNPSRMDRNVEMFMTIEK 129
            .::.|.|::|::||||||:||.||.|.:..::|:::|..:::||   :||:|.|.|:::.:.||:
  Fly    72 SADPPATRIPMRCFLDFKSGGGLCIIFSTMFRFRAEQRGKKFDFSIGKNPTRKDPNIQLLIEIEQ 136

Human   130 SLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNNASHVVYPVPGNLEEEEWVRPV 194
            :||:.:....|.|::.||||....|||::|:...:..:..|:.:|:|:||||. :...:|:.||:
  Fly   137 ALVEADLYRIPYIYIRPEIEKGFEGKLREILDNRRVEIVSDEEDATHIVYPVV-DPHPDEYARPI 200

Human   195 MKRDKQVLLHWGYYPDSYDTW----------IPASEIEASVEDAPTPEKPRKVHAKWILDTDTFN 249
            .||...|:|||.|:|:|||:|          ||        |:..:|.:..:|.|.||:|.:.:|
  Fly   201 FKRGGHVMLHWYYFPESYDSWAVNNFDLPDHIP--------ENPESPAERWRVSASWIVDLEQYN 257

Human   250 EWMNEEDYEVNDDKNPVSRRKKISAKTLT---DEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEA 311
            |||.||||||::.....:.::::|...:.   ||...|.:    ..||..:||:|||||:.:...
  Fly   258 EWMAEEDYEVDEQGKKKTHKQRMSIDDIMSFGDEKKKPAA----SSGGGKQKRRRSPSPASSAST 318

Human   312 KKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEV-----TLPKTVN------TKK 365
            .|...:|  .:|....|:...:::.||||:|:|:|...|||:||     .|..|.:      ::.
  Fly   319 SKPGKRK--RSPAVVHKKSRNDDDDEDLTRDLDDPPAEPNVQEVHKANAALQSTASPAPGGKSRG 381

Human   366 DSESAPVKGGTMTDLDEQ-----EDESMET-------TGKDEDENSTGNKGEQTKNPDLHEDNVT 418
            |::..|:|||||||||::     ..::|.|       |||..|.::|.......|. |: |||||
  Fly   382 DNDMMPIKGGTMTDLDDEMTGGSAAQAMSTGDGENSQTGKTSDNSNTQEFSSSAKE-DM-EDNVT 444

Human   419 EQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTS 483
            |||||||:|||:|||||||:|.||:||:|||||.||||||||||:||||||||||||||.|||||
  Fly   445 EQTHHIIVPSYSAWFDYNSIHVIEKRAMPEFFNSKNKSKTPEIYMAYRNFMIDTYRLNPTEYLTS 509

Human   484 TACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQP-K 547
            ||||||||||||||||||||||||||||||:||:.||||||||||||||:|:||||||..:.| |
  Fly   510 TACRRNLAGDVCAIMRVHAFLEQWGLINYQIDADVRPTPMGPPPTSHFHILSDTPSGLQSINPQK 574

Human   548 TPQGRQ----VDADTKAGRK--GKELDDLVPETAKGKPELQTSASQQMLNFPDKGKEKPTDMQNF 606
            |.|...    :|.|.|...|  |.||.|....|......|:..|:..:          .:.:..|
  Fly   575 TQQPSAAKTLLDLDKKPLGKDGGLELGDKSGLTGIKTEALENGAAGGL----------SSGVSQF 629

Human   607 GLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFL 671
            ||:.|.|.||....:::.|||..||||:||||||||.|||:|||||||.||||||||||||||||
  Fly   630 GLKLDQYAKKPAAMRNRTAASMAREWTDQETLLLLEGLEMHKDDWNKVCEHVGSRTQDECILHFL 694

Human   672 RLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKE 736
            |||||||||||....|||||.||||||:||||:||||||||||||||||:||||:|:|||:.:|:
  Fly   695 RLPIEDPYLEDDGGFLGPLACQPIPFSKSGNPIMSTVAFLASVVDPRVAAAAAKAAMEEFAAIKD 759

Human   737 EVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATDEKK 801
            |||..:::.|::.||:|: ..||.:|.|||.:||||||           |||            |
  Fly   760 EVPATIMDNHLKNVEKAS-AGGKFNPNFGLANSGIAGT-----------GND------------K 800

Human   802 EPKEPREGG-----GAIEEEAKE---KTSEAPKKDEEK------------------GKEGDSEKE 840
            :.:|.:|||     |..:||.|:   |..:|..||..|                  |...:::|:
  Fly   801 DDEEGKEGGASASAGGSDEEMKDLSKKDDDAKSKDNTKSDKTNTNTDSSSTSSSATGNTNNTDKK 865

Human   841 SEKSDG-DPIVDPEKEKEPKE--------------GQEEVLKEVVESEGERKTKVERDIG----- 885
            .::|.| .|..|....|..|.              |:.::..|....:||.|...|...|
  Fly   866 PKESSGSSPSGDKSAIKSDKSNKSSPTETAAAASGGEVDIKTEDSSGDGETKDGTEAKEGTGTGT 930

Human   886 ------------EGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFE 938
                        |.|:.||||||||:||||||||||:||||||||||||||||||||||||||||
  Fly   931 GPLAVPKEGTFSENNMQTAAAAALASAAVKAKHLAALEERKIKSLVALLVETQMKKLEIKLRHFE 995

Human   939 ELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQ---------------- 987
            |||..|:||||.||||||||:.:||.||:||||.||.|||||...::.|
  Fly   996 ELEATMEREREGLEYQRQQLITERQQFHLEQLKAAEFRARQQAHHRLQQELQGQAAAGSMILPQQ 1060

Human   988 -----------------------QQQQPPP---ALPPGSQPIPPTGAAGPPAVHGLAVAPASVVP 1026
                                   ||||.||   .|||.|||:     |||.|.|  ...|..||.
  Fly  1061 QQLPQAQQPQQQQQTLPPHPHLAQQQQLPPHPHQLPPQSQPL-----AGPTAQH--QPLPPHVVS 1118

Human  1027 APAGS--GAPPGSLGPSEQIGQAGSTAGPQQQQPAGAPQPGAVPPGVP------PPGPHGP---- 1079
            :|.|:  .|||.||                         .|.:|||.|      |....||
  Fly  1119 SPNGAPFAAPPISL-------------------------TGGLPPGAPTAIVTNPSDQTGPVAAG 1158

Human  1080 -----SPFPNQQTPPSMMP----GAVPGSGHPGVAGNAPLGLPFGMPPPPPPPAPSIIP 1129
                 :|.|...||||..|    .|.|||..|          |.|:||....|...:.|
  Fly  1159 AAQSQAPTPMDTTPPSSGPVSDANAPPGSAMP----------PGGIPPANTAPIAGVAP 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC2	NP_001317217.1	SWIRM-assoc_2	4..420	CDD:465143	161/455 (35%)
		RSC8	379..>739	CDD:227584	241/378 (64%)
		SWIRM-assoc_3	715..781	CDD:465145	34/65 (52%)
		PTZ00121	<721..978	CDD:173412	135/314 (43%)
		SWIRM-assoc_1	<911..977	CDD:465142	54/65 (83%)
		PHA03247	<999..1234	CDD:223021	44/152 (29%)
mor	NP_524373.1	SWIRM-assoc_2	6..446	CDD:465143	161/455 (35%)
		RSC8	417..>742	CDD:227584	223/336 (66%)
		SWIRM-assoc_3	738..803	CDD:465145	38/88 (43%)
		DUF4670	<863..1049	CDD:464815	94/185 (51%)
		SWIRM-assoc_1	962..1031	CDD:465142	57/68 (84%)
		PHA03247	<1100..1209	CDD:223021	43/150 (29%)