Protein Alignment SMARCC2 and swsn-1

DIOPT Version :10

• Sequence 1: NP_001317217.1
• Gene: SMARCC2 / 6601
• HGNCID: 11105
• Length: 1245
• Species: Homo sapiens
• Sequence 2: NP_001256907.1
• Gene: swsn-1 / 180324
• WormBaseID: WBGene00004203
• Length: 792
• Species: Caenorhabditis elegans
• Alignment Length: 940
• Identity: 389/940 - (41%)
• Similarity: 498/940 - (52%)
• Gaps: 258/940 - (27%)

Human   317 KKGPSTPYTKSKRGHREEEQED--LTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTD 379
            |||      .||| .|:::..|  :|.| |:.|......:|.:||  ..:||:|.:..||..:||
 Worm     2 KKG------ASKR-RRDDDDGDVSMTGD-DDDSRSGAAVKVEVPK--GKEKDAEFSAPKGQKLTD 56

Human   380 LDEQEDESMETTGKDEDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERR 444
            |||   |.:::|               .:.|.|.|.||.||||:|::||||.|||||::|.||:|
 Worm    57 LDE---EGVQST---------------KEAPQLAEGNVIEQTHYIVVPSYAGWFDYNAIHQIEKR 103

Human   445 ALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGL 509
            |:|||||||||||||::|:||||||:|||||||.||:::||||||||||||:|:|:|:|||||||
 Worm   104 AMPEFFNGKNKSKTPDVYVAYRNFMVDTYRLNPFEYVSATACRRNLAGDVCSIVRLHSFLEQWGL 168

Human   510 INYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKELDDLVPET 574
            :|||||:::||.|:.|||||||.||||||:|   :||..|.|::     .||..|:      |..
 Worm   169 LNYQVDSDARPAPVAPPPTSHFMVLADTPTG---IQPMNPPGKE-----SAGASGE------PPK 219

Human   575 AKGKPELQTSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLL 639
            .:.|.|:::.::.                   ||:.|.|.|:.:..::|.|... |:||||||.|
 Worm   220 EEIKTEIESISTP-------------------GLKIDQYQKQAIAMRTKGAPPG-RDWTEQETCL 264

Human   640 LLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEAS--------------LGPL 690
            |||||||:|||||||.:|||:|||.||:|.||:|||:||||.::.:|              ||||
 Worm   265 LLEALEMFKDDWNKVCDHVGTRTQHECVLKFLQLPIQDPYLTENLSSDKAEAAPGGAAKEVLGPL 329

Human   691 AYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAK 755
            |:||:||||||||||||||||||||||:||:||.|:|:|||.|:|||:|..:.|||.:.|...|:
 Worm   330 AFQPVPFSQSGNPVMSTVAFLASVVDPQVAAAATKAAMEEFGKLKEEIPPLVAEAHEKNVAAMAE 394

Human   756 VTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATDEKKEPKEPREGGGAIEEEAKEK 820
            .||:.|.|.||..||:
 Worm   395 KTGQVDGAVGLTKSGL------------------------------------------------- 410

Human   821 TSEAPKKDEEKGKEGDSEKESEKSDGDPIVDPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIG 885
                 |..||..  |||:::.:.:..|.                     |.|..|.|:.:::.:
 Worm   411 -----KPAEEAA--GDSDEKMDTNTNDD---------------------VPSTTEAKSAIDKGV- 446

Human   886 EGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREA 950
                ..|||:.||||||||||||.:|||:||||||.||||||||||:|||||:|||.|||:|||:
 Worm   447 ----QAAAASCLAAAAVKAKHLAQIEERRIKSLVAQLVETQMKKLEMKLRHFDELEQIMDKERES 507

Human   951 LEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQPPPALPPG------SQPIP----- 1004
            |||||.||:.:||||||:||||.|.||:.:...:| ......|..||||      .||.|
 Worm   508 LEYQRHQLILERQAFHMDQLKYLENRAKHEAHSRM-TSSGALPAGLPPGFEVTGPPQPTPQVQIS 571

Human  1005 --------------PTGAAGPPAVHGLAVAP-----ASVVPAPAGSGAPP-------GSLGPSEQ 1043
                          ...||.||:......||     .:.|.||....|||       |..||.:|
 Worm   572 AQEAAIPEKMDTSEAATAARPPSTPQAPQAPPVQAAPAPVQAPQAPQAPPQAYQGYGGPGGPPQQ 636

Human  1044 I-------GQAGSTAGPQQQQ---------------PAGAPQPGAVPP-------GVPPPG-PHG 1078
            .       ||..|...|.|||               |.|..|....||       |.|||| |:|
 Worm   637 AYRYPPQQGQQYSPYPPPQQQQQHQAQQAQSQAHYGPPGGGQGPPPPPQGQQYYGGPPPPGQPYG 701

Human  1079 PS---PFPNQQTPP---SMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPP---PAPSIIPFGSLA 1134
            |.   | |.||.||   ...||..|.....|          :|.||||.|   ..|...|:|
 Worm   702 PPGGYP-PQQQRPPYQAQPYPGPPPPQQQRG----------YGYPPPPQPVFSGHPYQQPYG--- 752

Human  1135 DSISINLPAPPNLHGHHHHLPFAPGTLPPP 1164
                 .:|.||  ||.:.......|.:.||
 Worm   753 -----QMPPPP--HGQYQPQQQQGGPMGPP 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC2	NP_001317217.1	SWIRM-assoc_2	4..420	CDD:465143	32/104 (31%)
		RSC8	379..>739	CDD:227584	203/373 (54%)
		SWIRM-assoc_3	715..781	CDD:465145	30/65 (46%)
		PTZ00121	<721..978	CDD:173412	103/256 (40%)
		SWIRM-assoc_1	<911..977	CDD:465142	51/65 (78%)
		PHA03247	<999..1234	CDD:223021	67/242 (28%)
swsn-1	NP_001256907.1	RSC8	33..509	CDD:227584	285/611 (47%)
		SWIRM-assoc_3	354..419	CDD:465145	33/120 (28%)