DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCC2 and smarcc2

DIOPT Version :10

Sequence 1:NP_001317217.1 Gene:SMARCC2 / 6601 HGNCID:11105 Length:1245 Species:Homo sapiens
Sequence 2:XP_004911932.1 Gene:smarcc2 / 100101794 XenbaseID:XB-GENE-490675 Length:1178 Species:Xenopus tropicalis


Alignment Length:1273 Identity:931/1273 - (73%)
Similarity:1015/1273 - (79%) Gaps:124/1273 - (9%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFG 65
            |||||||||||||:|||:|||.|||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MAVRKKDGGPNVKFYEASDTVAQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFG 65

Human    66 KHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKS 130
            ||||||||||||:|||||||..|:|.|||||||||||||||||:|||||||||||||||||||||
 Frog    66 KHVSNAPLTKLPMKCFLDFKVSGALSHILAAAYKFKSDQGWRRFDFQNPSRMDRNVEMFMTIEKS 130

Human   131 LVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNNASHVVYPVPGNLEEEEWVRPVM 195
            ||||||||||||:|.|:|:.||..|||||:|||||||||||::|||:|.|||.|||:||||||::
 Frog   131 LVQNNCLSRPNIYLHPDIDSKLQSKLKDIVKRHQGTVTEDKSHASHIVVPVPSNLEDEEWVRPIL 195

Human   196 KRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVN 260
            ||||||||||||||||||||:||||:|||||||||.|||||||||||||||:|||||||||||:.
 Frog   196 KRDKQVLLHWGYYPDSYDTWVPASEVEASVEDAPTVEKPRKVHAKWILDTDSFNEWMNEEDYELT 260

Human   261 DDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYT 325
            |:||||:||||||||||||||:|||||||||||.|||||||||||.|:.|||||..|||||||||
 Frog   261 DEKNPVARRKKISAKTLTDEVSSPDSDRRDKKGPNYKKRKRSPSPPPSAEAKKKTVKKGPSTPYT 325

Human   326 KSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMET 390
            ||||||||||||||||||||||||||||||||||||||||||||||:||||:|||||||||||:.
 Frog   326 KSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPIKGGTVTDLDEQEDESMDA 390

Human   391 TGKDEDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNK 455
            ..|:|||.|:|.||||.|..|||||||||||||||||||||||||||||||||||||||||||||
 Frog   391 VTKEEDETSSGIKGEQMKTSDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNK 455

Human   456 SKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRP 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   456 SKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRP 520

Human   521 TPMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKELDDLVPETAKGKPELQTSA 585
            ||||||||||||||||||||||||||||||                               |:||
 Frog   521 TPMGPPPTSHFHVLADTPSGLVPLQPKTPQ-------------------------------QSSA 554

Human   586 SQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDD 650
            ||||||||||.|:||:|:||||||||||:|||..|||||||||||||||||||||||||||||||
 Frog   555 SQQMLNFPDKSKDKPSDLQNFGLRTDMYSKKNTTSKSKAAASATREWTEQETLLLLEALEMYKDD 619

Human   651 WNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVV 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   620 WNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVV 684

Human   716 DPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPE 780
            |||||||||||||:||||||||||||||||||||||:||::||||||::||||||||||..::.|
 Frog   685 DPRVASAAAKSALDEFSKMKEEVPTALVEAHVRKVEDAARITGKADPSYGLESSGIAGTACEDNE 749

Human   781 RI-----------EESGNDEARVEGQATDEKKEPKE-PREGGGAIEEEAKEKTSEAPKKDEEKGK 833
            ||           |||.:||.:.:.|.|::|||||: |.|  ...|||.|||.||..||:|||.|
 Frog   750 RIDCPKRSTPEIHEESSSDEPQTDAQPTEDKKEPKDSPSE--TLPEEEGKEKISEVAKKEEEKSK 812

Human   834 EGDSEKESEKSDGDPIVDPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALA 898
            :||::|||||||.| :.|.||..:.|||.||:.||    ||..|.||||||||||||||||||||
 Frog   813 DGDTDKESEKSDID-MADGEKVSDTKEGVEEIEKE----EGGGKNKVERDIGEGNLSTAAAAALA 872

Human   899 AAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 963
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   873 AAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 937

Human   964 AFHMEQLKYAEMRARQQHFQQM---HQQQQQPPPALPPGSQPIPPTGAAGPPAVHGLAVAPASVV 1025
            .||||||||||:|||||||||:   ||||||...:    |||:||||       |.::.:.:|::
 Frog   938 NFHMEQLKYAEIRARQQHFQQIQNQHQQQQQTTSS----SQPVPPTG-------HSVSGSQSSLI 991

Human  1026 PAPAGSGAPPGSLG-PSEQIGQAGSTAGP---QQQQPAGAPQPGAVPPGVPPPGPHGPSPFPNQQ 1086
            .||..|.:...||| ||     |.||..|   ||||....|.|.           |....|.:||
 Frog   992 QAPVSSASNAESLGQPS-----APSTQPPVSSQQQQGGTQPSPA-----------HPSGTFTSQQ 1040

Human  1087 TPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPPPA---PSI-IPF-----GSLADSISINLP 1142
            :...::|.||                  .:|..||.|.   ||: :|.     ..|.||:..| |
 Frog  1041 SSTPLVPSAV------------------SVPAQPPVPGNQHPSMHLPVQYNLASELVDSVHHN-P 1086

Human  1143 APPNLHGHHHHLPFAPGTLPPPNLPVSMANPLHPNLPA-TTTMPSSLPLGPGLGSAAAQSPAIVA 1206
            : .||:..||.:   .||.||....|. ..||.|:.|: ..:..|:||  ..|||||..||||||
 Frog  1087 S-TNLYTPHHPM---HGTFPPAACRVG-GGPLTPHNPSIMVSSASNLP--SNLGSAATHSPAIVA 1144

Human  1207 AVQGNLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPP 1244
            |:||.:..:.||:|||.||||||    |.|.....|.|
 Frog  1145 AMQGGVALTTSPVPDPATPLPPD----SIGNTVAQPQP 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCC2NP_001317217.1 SWIRM-assoc_2 4..420 CDD:465143 362/415 (87%)
RSC8 379..>739 CDD:227584 308/359 (86%)
SWIRM-assoc_3 715..781 CDD:465145 54/65 (83%)
PTZ00121 <721..978 CDD:173412 198/268 (74%)
SWIRM-assoc_1 <911..977 CDD:465142 63/65 (97%)
PHA03247 <999..1234 CDD:223021 87/248 (35%)
smarcc2XP_004911932.1 SWIRM-assoc_2 4..420 CDD:465143 362/415 (87%)
RSC8 382..>690 CDD:227584 288/338 (85%)
SWIRM-assoc_3 684..750 CDD:465145 54/65 (83%)
COG5137 <763..831 CDD:227466 39/70 (56%)
SWIRM-assoc_1 <885..951 CDD:465142 63/65 (97%)
Atrophin-1 986..>1178 CDD:460830 82/237 (35%)

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