DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMX and LSB1

DIOPT Version :9

Sequence 1:	NP_001712.1	Gene:	BMX / 660	HGNCID:	1079	Length:	675	Species:	Homo sapiens
Sequence 2:	NP_011652.1	Gene:	LSB1 / 853037	SGDID:	S000003368	Length:	241	Species:	Saccharomyces cerevisiae

Alignment Length:	244	Identity:	46/244 - (18%)
Similarity:	82/244 - (33%)	Gaps:	74/244 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    22 SPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSI-EIKKIRCVEKVNLEEQTP--------VERQ 77
            |..|.:..|..|.::|:.            .|.| |:...:..||.:..:::|        ||..
Yeast     9 SLKNIRNELEFLKESNVI------------SGDIFELINSKLPEKWDGNQRSPQNADTEEYVEAL 61

Human    78 YPFQIVYKDGLLYVYASNEESRSQWLKALQK----EIRGNPHLLVKYHSGFFVDGKFL--CCQQS 136
            |.|: ..:||.|.:...::      ::.|:|    ..||..:..:......:|...|.  ...:|
Yeast    62 YDFE-AQQDGDLSLKTGDK------IQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASPKS 119

Human   137 CKAAPGCTLWEAYANLHTAVNEEKHRVP---------TFPDRVLKIPRAVPVLKMDAPSSSTTLA 192
            .:||...|:             .:..||         .:|.:.:..|.|.|...|.||......|
Yeast   120 AEAASSSTV-------------SRPSVPPPSYEPAASQYPSQQVSAPYAPPAGYMQAPPPQQQQA 171

Human   193 ---------QYDNESKKNYG---------SQPPSSSTSLAQYDSNSKKI 223
                     .|..:.::.|.         :||..||.:.:.:.|...|:
Yeast   172 PLPYPPPFTNYYQQPQQQYAPPSQQAPVEAQPQQSSGASSAFKSFGSKL 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	28/139 (20%)
		SH2_Tec_Bmx	289..394	CDD:198262
		PTKc_Btk_Bmx	412..667	CDD:173657
		CAV1-binding	596..603
LSB1	NP_011652.1	SH3	55..108	CDD:214620	11/59 (19%)
LSB1	NP_011652.1	PRK14971	<100..>156	CDD:237874	10/68 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000