DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMX and itk

DIOPT Version :9

Sequence 1:	NP_001712.1	Gene:	BMX / 660	HGNCID:	1079	Length:	675	Species:	Homo sapiens
Sequence 2:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio

Alignment Length:	687	Identity:	295/687 - (42%)
Similarity:	410/687 - (59%)	Gaps:	87/687 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEK 65
            |..:.||:|.|.|:||||::.||.|||||.|:|...:|:|:|....|:.::||.||:..|:|||.
Zfish     1 MYPRVILKETLYKKSQQKRRTSPCNYKERTFILNTQDLAYFEQRPGKKPTQKGCIELSHIKCVEI 65

Human    66 VNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKF 130
            |..:...|.:.:|||||::....|||:|.:.:.|.:|:|||::.|:.| .|.:|||..|:.:||:
Zfish    66 VRSDVPIPCDYKYPFQIIHDSYYLYVFAPDNDCRLKWVKALKEAIQNN-SLFLKYHPDFWGEGKW 129

Human   131 LCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYD 195
            .||||:.|.|.||:  |.|.|       ....:|..||         |..:...|.....:|
Zfish   130 RCCQQTEKLATGCS--EYYPN-------GAKPLPPTPD---------PSRRSSEPEERIVVA--- 173

Human   196 NESKKNYGSQPPSSSTSL-AQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVA 259
               .:|:   .|...|.| .|.|.....:..|:||             ||.|:
Zfish   174 ---LRNF---IPKEHTDLPLQKDEEYFIVDCSEPN-------------WWTVK------------ 207

Human   260 SSNQKERNVN-----HTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAF 319
               .|:.||.     :.|.|:|            .|::.::|:..:|:|:::|.||.|:.|:|.|
Zfish   208 ---DKDGNVGSVPCIYVTEKLS------------NNIEKFEWYNKDINRTEAEDLLMQENKDGGF 257

Human   320 MVRNSSQVGMYTVSLFSK---AVNDKKGTVKHYHVHTNAENK---LYLAENYCFDSIPKLIHYHQ 378
            |||||...|:||||:|::   :..:|...||||.:...:|.:   .||||.|.|.:||:||.|||
Zfish   258 MVRNSKHAGVYTVSIFTRVSGSNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQ 322

Human   379 HNSAGMITRLRHPVSTKANKVPDSV---SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQY 440
            ||.||:||||||.||   ..||:|.   .|.:..||:..:|:.|..||||||||:|..|.|:.:
Zfish   323 HNPAGLITRLRHCVS---RNVPNSARIKELSSDKWEIHPDEVKLSVELGSGQFGLVWKGSWQDR- 383

Human   441 DVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG 505
            :||||.::||.|||:||.:|||.||||||.:||:.|||.::..|||:|.|::.||||..:||:..
Zfish   384 EVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKK 448

Human   506 KGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSV 570
            ..|....|||||.||.||||:|||..|||||||||||||..:..||::||||||:||||||.||.
Zfish   449 GKLSQKALLEMCLDVSEGMAYLESSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSSH 513

Human   571 GTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPH 635
            |:||||:||:|||..:.|||||||||:||:.||||:|.|:.|||...||:||..::.||||.:|.
Zfish   514 GSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPR 578

Human   636 LASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREK 672
            |...::|::|...|.|.||.||:|..||..:..|.::
Zfish   579 LCPQSVYELMQWSWKEKPEDRPSFALLLHELACLDQE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	62/139 (45%)
		SH2_Tec_Bmx	289..394	CDD:198262	52/110 (47%)
		PTKc_Btk_Bmx	412..667	CDD:173657	144/254 (57%)
		CAV1-binding	596..603		3/6 (50%)
itk	NP_571179.1	PH	5..110	CDD:278594	46/104 (44%)
		PH_Btk	7..147	CDD:269944	63/142 (44%)
		SH3_Tec_like	170..223	CDD:212702	16/89 (18%)
		SH2_Tec_family	227..338	CDD:198188	53/113 (47%)
		PKc_like	356..610	CDD:304357	144/254 (57%)
		Pkinase_Tyr	361..609	CDD:285015	143/248 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810