DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMX and tec

DIOPT Version :9

Sequence 1:	NP_001712.1	Gene:	BMX / 660	HGNCID:	1079	Length:	675	Species:	Homo sapiens
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	665	Identity:	299/665 - (44%)
Similarity:	418/665 - (62%)	Gaps:	71/665 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEK 65
            |....||||.|:|||||||:.||.|||||:|||||:.|:|||....|| .:|||:::::::|||.
Zfish     1 MSLPHILEETLIKRSQQKKRTSPLNYKERVFVLTKSKLTYYELRAEKR-FKKGSVDLQRVKCVEI 64

Human    66 V-NLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGK 129
            | |.....|.:.:||||:||....||::|.:.||||.|::.:::|||.||.:..||||.|:.:|:
Zfish    65 VKNNTTVIPCQNKYPFQVVYDSSTLYIFAPSNESRSVWVQNIKEEIRNNPLIADKYHSQFWQEGE 129

Human   130 FLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPD---------RVLKIPRAVPVLKMDAP 185
            :|||.|..|.||||   |.| ||...|:.:.  :|..|:         |....|......:.:.|
Zfish   130 WLCCGQVDKLAPGC---EGY-NLFGDVSRKP--LPPVPEDQNISCTGRRPPPPPPGETKQEEEEP 188

Human   186 SSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFP-DWWQVRKL 249
            .....:|.||.|     |.:|...:....:                 :|:..|... :|:   |.
Zfish   189 EEEVVIALYDFE-----GLEPHDLTLKTGE-----------------EYVILEKCEVNWY---KA 228

Human   250 KSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKG 314
            ::....:....|       |:.|.|.|            :.|:.:.||:.|::|:::|:|||::|
Zfish   229 RNKEGKQGYIPS-------NYVTEKAS------------DKLEQFIWFSKNVNRNKAEELLRKEG 274

Human   315 KEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHY---HVHTNAENKLYLAENYCFDSIPKLIHY 376
            |||.||||.||..|.|||||::|:.:|....::||   .:|.:.: :.||||.|.|.|||:||.|
Zfish   275 KEGGFMVRLSSNTGTYTVSLYTKSTSDGAAAIRHYQIKEIHASPK-QFYLAEKYIFTSIPELIEY 338

Human   377 HQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYD 441
            |:||:||:::||||.|..:..:.|.:.......||:...|:|.:|||||||||||:||||:.|:.
Zfish   339 HKHNAAGLVSRLRHAVGDQKREAPTTAGFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRAQHK 403

Human   442 VAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGK 506
            ||:|.|:||:||||:|.:||:.||.|||..||:.||||:::.|||:|||::..|||||:||....
Zfish   404 VAIKTIREGAMSEDDFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRG 468

Human   507 GLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVG 571
            .|....||.:|:|:.:||..||.::|||||||||||||:..:.|||||||||||||||||.||.|
Zfish   469 TLAAQDLLGICHDISQGMQHLEENRFIHRDLAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSG 533

Human   572 TKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHL 636
            ||||||||.||||::.:||||||||:||:||||||:.||.|::...|.:|||.|:||||||||..
Zfish   534 TKFPVKWSPPEVFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRPKK 598

Human   637 ASDTIYQIMYSCWHE 651
            :|.:..|     :||
Zfish   599 SSSSHLQ-----YHE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	72/140 (51%)
		SH2_Tec_Bmx	289..394	CDD:198262	52/107 (49%)
		PTKc_Btk_Bmx	412..667	CDD:173657	145/240 (60%)
		CAV1-binding	596..603		4/6 (67%)
tec	NP_001108215.1	PH	6..111	CDD:278594	54/105 (51%)
		PH_Btk	7..148	CDD:269944	74/145 (51%)
		SH3_Tec	192..246	CDD:212838	13/85 (15%)
		SH2_Tec_Itk	249..356	CDD:198259	52/107 (49%)
		PKc_like	374..602	CDD:304357	142/227 (63%)
		Pkinase_Tyr	379..602	CDD:285015	141/222 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810