DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMX and btk

DIOPT Version :9

Sequence 1:	NP_001712.1	Gene:	BMX / 660	HGNCID:	1079	Length:	675	Species:	Homo sapiens
Sequence 2:	XP_021336920.1	Gene:	btk / 568653	ZFINID:	ZDB-GENE-070531-1	Length:	640	Species:	Danio rerio

Alignment Length:	685	Identity:	318/685 - (46%)
Similarity:	447/685 - (65%)	Gaps:	77/685 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     6 ILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYD--KMKRGSRKGSIEIKKIRCVEKVNL 68
            :|||:.:||||||||.||.|:||||||||...:|||:||  |.||.|.||.::|:||||||.|..
Zfish     5 VLEEVFIKRSQQKKKTSPLNFKERLFVLTHDKISYYDYDAEKAKRKSLKGYVDIEKIRCVEVVLP 69

Human    69 EEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCC 133
            |:..|.:|.|||||||.:|.|||:|.:::.|..|:..|:..:|.|..|:.|||..|:.||.:.||
Zfish    70 EDSAPPDRHYPFQIVYDEGPLYVFAKSDQIRKHWIHELKNVVRFNKDLMQKYHPCFWEDGVWKCC 134

Human   134 QQSCKAAPGCTLWEAYANLHTAVNEEKHR-----VPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQ 193
            .|..|.|.||.:.|. .|........|:|     :|..|:.. |..|.:|   .:.|
Zfish   135 LQEVKQAMGCRVLET-KNGGVFKRGSKNRDSRKPLPPTPEEE-KPARPLP---PEPP-------- 186

Human   194 YDNESKKNYGSQPPSSS---TSLAQYDSNSKKIYGSQPNFNMQYIPREDF-------PDWWQVRK 248
                       .||:.|   |.:|:|:      |......:::....|::       |:|:   |
Zfish   187 -----------MPPAFSIGMTVIAEYE------YAPMTTNDLELRKDEEYTLLEISDPNWF---K 231

Human   249 LKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQK 313
            .|.....|....||...:.:|                    .|:.|||:..||:|||:|.||:.:
Zfish   232 AKDKYGKEGYIPSNYIVQALN--------------------GLEKYDWYCKNINRSQAENLLKTE 276

Human   314 GKEGAFMVRNSSQ-VGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYH 377
            .|:|.|:||:|.: .|.||||:|:||..:..|:.:||::...|:.:.||||.:.|.:||:||:||
Zfish   277 NKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRHYNILLTADGQFYLAEKHNFTNIPELINYH 341

Human   378 QHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDV 442
            |||:||:::||::.||.:|...|.:..||.|.||:...::|.::|||:||||||:.|||:|::||
Zfish   342 QHNAAGLVSRLKYIVSNRAQNAPCTAGLGYGSWEIDPRQLTFIRELGNGQFGVVKYGKWQGRHDV 406

Human   443 AVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKG 507
            |:||:||||||||:|.:||:.||||.|..||:.||||:|:.||||||||::||||||||:   :|
Zfish   407 AIKMVKEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQ---EG 468

Human   508 -LEPSQ--LLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS 569
             |.|:.  |||||.||.|||.:||::|||||||||||||||.:..:||:|||::||||||:|.||
Zfish   469 LLNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSS 533

Human   570 VGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRP 634
            ||:||||:||.|||..|.|:|||||:||||:||||:::.|:.|||.::|:::|.|:|.|||||||
Zfish   534 VGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRP 598

Human   635 HLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669
            .:|::.::.||.|||||.|::|||||:|:..|:.|
Zfish   599 QMANENVFAIMNSCWHERPDERPTFQELVGVIKDL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	75/141 (53%)
		SH2_Tec_Bmx	289..394	CDD:198262	49/105 (47%)
		PTKc_Btk_Bmx	412..667	CDD:173657	158/257 (61%)
		CAV1-binding	596..603		5/6 (83%)
btk	XP_021336920.1	PH_Btk	6..145	CDD:269944	74/138 (54%)
		SH3	195..249	CDD:327375	12/62 (19%)
		SH2	252..357	CDD:326550	49/124 (40%)
		PKc_like	376..630	CDD:328722	158/256 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810