Protein Alignment BMX and Btk29A

DIOPT Version :9

• Sequence 1: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 771
• Identity: 284/771 - (36%)
• Similarity: 407/771 - (52%)
• Gaps: 156/771 - (20%)

Human    11 LLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEK--VNLEEQTP 73
            ::||:|.||:.:|.|||.|.|.|||...||::.:.::|...:|.|.:|.:|.||:  |:.|...|
  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112

Human    74 VERQ-YPFQIVY------------KDG---------------------LLYVYASNEESRSQWLK 104
            .... ||||:.|            ::|                     .|||.|::|:.||:|::
  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177

Human   105 ALQKEIR-GNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPD 168
            |:::... .|.....:||.|.:...|:.||:...:...||   .|.|:...|.|...:......:
  Fly   178 AIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGC---RAAAHWREANNNPSNGSSPAQN 239

Human   169 RVLKIPRAVPVLKMDAPSSSTTLAQY--DNESKKNYGS--------------------------- 204
            ....|          :|:||||.:|:  .:.|..:.|.
  Fly   240 STRSI----------SPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPT 294

Human   205 --QPPSSSTSLAQ-----------YDSNS------------------------------KKIYGS 226
              ||.||.|:..|           .|:|.                              |.|.|.
  Fly   295 SLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGG 359

Human   227 QPNF--NMQYIPREDFPD-WWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEE 288
            ..:.  |.:|...:|..: ||:|:....               ||.:..|  ::..|::..
  Fly   360 DLSLEKNAEYEVIDDSQEHWWKVKDALG---------------NVGYIPS--NYVKPKALL---- 403

Human   289 ENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHT 353
             .|:.|:|:.|::||.::|.||:|..|||.|:||.||..|:||:||.:|.   .:..|||||:..
  Fly   404 -GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQ 464

Human   354 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANK-VPDSVSLGNGIWELKREEI 417
            ||..:.||:|.:|.::||.||:||:|||.|:..||:   |:..:: ||.:..|.:..||:...|:
  Fly   465 NARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK---SSPCDRPVPPTAGLSHDKWEIHPMEL 526

Human   418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKE 482
            .|::||||||||||:.|||:|..|.||||:|||:||||:|.:||:.|.||.||.||:.||||||.
  Fly   527 MLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591

Human   483 YPIYIVTEYISNGCLLNYLRSHGKGL--EPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD 545
            .||||||||:.:|.||||||.|.|.|  ....||:||..|.:||.:||.|.:||||||||||||.
  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656

Human   546 RDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGK 610
            .:..|||:|||:.||||||||.||.|||||:||:.|||.:|.::||||||||:|:||||:|:.||
  Fly   657 SENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGK 721

Human   611 QPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSI 666
            .||....|::||.:|.:|..|.:|...:..||.:|..||...||:||.|:.|:..:
  Fly   722 MPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	50/172 (29%)
		SH2_Tec_Bmx	289..394	CDD:198262	47/104 (45%)
		PTKc_Btk_Bmx	412..667	CDD:173657	147/257 (57%)
		CAV1-binding	596..603		4/6 (67%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	51/176 (29%)
		SH3_Tec_like	346..399	CDD:212702	12/69 (17%)
		SH2_Tec_family	403..505	CDD:198188	48/112 (43%)
		PTKc_Tec_like	521..778	CDD:173637	147/257 (57%)
		Pkinase_Tyr	526..777	CDD:285015	146/250 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1267
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42091
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.910