DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCC1 and SWI3

DIOPT Version :10

Sequence 1:NP_003065.3 Gene:SMARCC1 / 6599 HGNCID:11104 Length:1105 Species:Homo sapiens
Sequence 2:NP_012359.1 Gene:SWI3 / 853264 SGDID:S000003712 Length:825 Species:Saccharomyces cerevisiae


Alignment Length:861 Identity:212/861 - (24%)
Similarity:345/861 - (40%) Gaps:287/861 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   181 ANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVH 245
            ||||..     |.|.:.|:|:|.:..     .||:|:........|..|..:....|.     :.
Yeast    83 ANKLDS-----QETPSTEESRAQNVF-----GQDNEDSDNLFGETESSVSNNEANTPS-----IP 132

Human   246 SNDVDAEIEDPPIPE----KPWKVHVKWILDTDIFNEWMNE---------EDYEVDENRKPVSFR 297
            :|.||.|...|.|.|    :.....||.:.|..|..|...|         |:.:.|||.|.:...
Yeast   133 TNPVDNENNKPAIKEDSTIQDSNGDVKNMEDVKIQKEEEPENNTVIEGVKEESQPDENTKEMDEV 197

Human   298 QRISTKNEEPVRSPE-------RRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGQASLYGKR 355
            :.....:::|:.||:       :.:.|...|.....::||..|                      
Yeast   198 EEDDEDDDQPMISPDNSIFGDTKSESKQLGNTSSVANTPSEIP---------------------- 240

Human   356 RSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLDEQDEETVTAGG 420
              ...:.||||:.:..|               :|:.|.||..         :.:||:.|.:    
Yeast   241 --DAHKAEQEDIIEKTE---------------SVDKKVDSGE---------ERNEQEREIM---- 275

Human   421 KEDEDPAKGDQSRSVDLGEDNVTE---------QTNHIIIPSYASWFDYNCIHVIERRALPEFFN 476
                    .|.|:|.:..:..:|.         |.:.|:||||:.||:...||.||.::|||||.
Yeast   276 --------NDHSKSANPKKTTITRVEPETFEIPQAHEIVIPSYSKWFNLEKIHSIEVQSLPEFFT 332

Human   477 GKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDP 541
            .:..|||||:|:.|||||:::|||||.||.:.|..|||::||..|:.|:|.||.:|||:|||||.
Yeast   333 NRIPSKTPEVYMRYRNFMVNSYRLNPNEYFSVTTARRNVSGDAAALFRLHKFLTKWGLINYQVDS 397

Human   542 ESRPMAMGPPPTPHFNVLADTPSGLVPLH-----LRSPQVPAAQQMLN----------FPEKNKE 591
            :..|..:.||.|..::...|.|.||.|..     ::.|.:...::|:|          :.:::|.
Yeast   398 KLLPKNIEPPLTSQYSTRHDAPRGLFPFESYKPSVQLPDMAKLKKMMNTSDSESTLYKYLKESKR 462

Human   592 K---------PVDLQNFGLRTDIYSKKTLAKSKGAS-------------------------AGRE 622
            |         ..|.:| |.:.|...|.....|...|                         ....
Yeast   463 KYDEITHPPSTTDDEN-GDKNDNGGKMNNEVSTSTSMTGDANLLEEGETSRPLKKVKILEQIDEN 526

Human   623 WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYL-------ENSDASLGP 680
            |::::...||:.::.:..||.||:::||:::.::|||.||:|||||.:|       .::|..|||
Yeast   527 WSKEDLQKLLKGIQEFGADWYKVAKNVGNKSPEQCILRFLQLPIEDKFLYGDGNGKGDNDNGLGP 591

Human   681 LAYQP-VPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEA 744
            |.|.| :|||:|.|||:||:|||..:|:|:...:..:.|::.                       
Yeast   592 LKYAPHLPFSKSENPVLSTIAFLVGLVNPKTVQSMTQRAIQS----------------------- 633

Human   745 ARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEKMEADPDGQQPEKAENKVENETDEGDKAQD 809
                                                                             
Yeast   634 ----------------------------------------------------------------- 633

Human   810 GENEKNSEKEQDSEVSEDTKSEEKETEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAAL 874
                           :|..||:::|..:                :|.:|| |.||     :..|:
Yeast   634 ---------------AESIKSQKEEISD----------------QKPIEH-IKEG-----SEIAI 661

Human   875 ASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTER 939
            :|...::...|..|||::..|...|:..||:||:.||.|.::||..|:.|::.||:|::.||.:|
Yeast   662 SSLGYRSHIFATNEERQMNFLTNELIRLQMEKLDAKLNHLKKLEKFMELERKTLERQQENLLIQR 726

Human   940 QNFHMEQLKYAELRAR 955
            .||:....|...:.::
Yeast   727 LNFNQNSSKIVNVLSK 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCC1NP_003065.3 MarR-like, BRCT and chromo domains module. /evidence=ECO:0000255|PROSITE-ProRule:PRU01376 28..302 33/133 (25%)
SWIRM-assoc_2 32..445 CDD:465143 57/292 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 296..439 23/149 (15%)
RSC8 444..>710 CDD:227584 116/331 (35%)
SWIRM-assoc_3 706..772 CDD:465145 3/65 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 745..860 6/114 (5%)
SWIRM-assoc_1 883..954 CDD:465142 26/70 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 956..1028 212/861 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1041..1105
SWI3NP_012359.1 RSC8 253..825 CDD:227584 167/652 (26%)
Blue background indicates that the domain is not in the aligned region.

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