Protein Alignment SMARCC1 and mor

DIOPT Version :10

• Sequence 1: NP_003065.3
• Gene: SMARCC1 / 6599
• HGNCID: 11104
• Length: 1105
• Species: Homo sapiens
• Sequence 2: NP_524373.1
• Gene: mor / 41942
• FlyBaseID: FBgn0002783
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 1232
• Identity: 538/1232 - (43%)
• Similarity: 725/1232 - (58%)
• Gaps: 196/1232 - (15%)

Human    33 RKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYV-HADAP-TNKTLAGLVVQLLQFQEDAFGKH 95
            :|||.|...|::||||:...:|:|.||.|:.|||: |:..| |.::||.|::..||:.|...||:
  Fly     7 KKDGSPNIDFFQSPETLQGFESIRQWLQKNCKKYLAHSSEPITKESLAQLLIHFLQYVEAKLGKN 71

Human    96 VTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDL---QNPSRMDRNVEMFMNIEK 157
            ..:|..|::|.:||:|||:||.||.|....::::.||..::||.   :||:|.|.|:::.:.||:
  Fly    72 SADPPATRIPMRCFLDFKSGGGLCIIFSTMFRFRAEQRGKKFDFSIGKNPTRKDPNIQLLIEIEQ 136

Human   158 TLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPV 222
            .||:.:....|.||:.|:|:.....||::|:...:.....::..|:|.:||......| |:.||:
  Fly   137 ALVEADLYRIPYIYIRPEIEKGFEGKLREILDNRRVEIVSDEEDATHIVYPVVDPHPD-EYARPI 200

Human   223 MRKEKQVLVHWGFYPDSYDTWVHSN-DVDAEI-EDPPIPEKPWKVHVKWILDTDIFNEWMNEEDY 285
            .::...|::||.::|:|||:|..:| |:...| |:|..|.:.|:|...||:|.:.:||||.||||
  Fly   201 FKRGGHVMLHWYYFPESYDSWAVNNFDLPDHIPENPESPAERWRVSASWIVDLEQYNEWMAEEDY 265

Human   286 EVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANA----RKRKHSPSPPPPTPTESRKKSGKK 346
            ||||..|..:.:||:|.   :.:.|.....:|.:|::    :||:.|||   |..:.|..|.||:
  Fly   266 EVDEQGKKKTHKQRMSI---DDIMSFGDEKKKPAASSGGGKQKRRRSPS---PASSASTSKPGKR 324

Human   347 GQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKK------------DSENTP 399
            .::.....::|:.::|: ||||:|::||...||::| |...|..|:.            |::..|
  Fly   325 KRSPAVVHKKSRNDDDD-EDLTRDLDDPPAEPNVQE-VHKANAALQSTASPAPGGKSRGDNDMMP 387

Human   400 VKGGTVADLDEQ-------------DEETVTAGGKEDEDPAKGDQSRSVDLGEDNVTEQTNHIII 451
            :||||:.|||::             |.|....|...|....:...|.:.:..||||||||:|||:
  Fly   388 IKGGTMTDLDDEMTGGSAAQAMSTGDGENSQTGKTSDNSNTQEFSSSAKEDMEDNVTEQTHHIIV 452

Human   452 PSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLT 516
            |||::|||||.|||||:||:|||||.||||||||||:||||||||||||||.||||||||||||.
  Fly   453 PSYSAWFDYNSIHVIEKRAMPEFFNSKNKSKTPEIYMAYRNFMIDTYRLNPTEYLTSTACRRNLA 517

Human   517 GDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVP-AAQ 580
            |||||:||||||||||||:|||:|.:.||..||||||.||::|:||||||..::.:..|.| ||:
  Fly   518 GDVCAIMRVHAFLEQWGLINYQIDADVRPTPMGPPPTSHFHILSDTPSGLQSINPQKTQQPSAAK 582

Human   581 QMLNFPEK--NKEKPVDL--------------------------QNFGLRTDIYSKKTLA--KSK 615
            .:|:..:|  .|:..::|                          ..|||:.|.|:||..|  ...
  Fly   583 TLLDLDKKPLGKDGGLELGDKSGLTGIKTEALENGAAGGLSSGVSQFGLKLDQYAKKPAAMRNRT 647

Human   616 GASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGP 680
            .||..||||:||||||||.|||:|||||||.||||||||||||||||||||||||||:....|||
  Fly   648 AASMAREWTDQETLLLLEGLEMHKDDWNKVCEHVGSRTQDECILHFLRLPIEDPYLEDDGGFLGP 712

Human   681 LAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAA 745
            ||.||:|||:||||:||||||||||||||||:||||||:|||:.:::|||..:::.|:|.|::|:
  Fly   713 LACQPIPFSKSGNPIMSTVAFLASVVDPRVAAAAAKAAMEEFAAIKDEVPATIMDNHLKNVEKAS 777

Human   746 RASGKVDPTYGLESSCIAGTGPDEPEKLEGAE----------EEKME---------ADPDGQQPE 791
             |.||.:|.:||.:|.|||||.|:.:: ||.|          :|:|:         ...|..:.:
  Fly   778 -AGGKFNPNFGLANSGIAGTGNDKDDE-EGKEGGASASAGGSDEEMKDLSKKDDDAKSKDNTKSD 840

Human   792 KAENKVE------------NETDEGDKAQDGENEK------NSEKEQDSEVSE----------DT 828
            |.....:            |.||:..|...|.:..      .|:|...|..:|          |.
  Fly   841 KTNTNTDSSSTSSSATGNTNNTDKKPKESSGSSPSGDKSAIKSDKSNKSSPTETAAAASGGEVDI 905

Human   829 KSEEKETE-ENKELTDTCKERESDTGKKKVEHE--ISEGNVATAAAAALASAATKAKHLAAVEER 890
            |:|:...: |.|:.|:..:...:.||...|..|  .||.|:.|||||||||||.|||||||:|||
  Fly   906 KTEDSSGDGETKDGTEAKEGTGTGTGPLAVPKEGTFSENNMQTAAAAALASAAVKAKHLAALEER 970

Human   891 KIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRAR 955
            ||||||||||||||||||||||||||||..|:||:|.||.|||||:||||.||:||||.||.|||
  Fly   971 KIKSLVALLVETQMKKLEIKLRHFEELEATMEREREGLEYQRQQLITERQQFHLEQLKAAEFRAR 1035

Human   956 QQM--------------------EQQQ--HGQNPQQAHQHSGGPGLAPLGAAGHPGMMPHQQPPP 998
            ||.                    :|||  ..|.|||..|     .|.|     ||.:...||.||
  Fly  1036 QQAHHRLQQELQGQAAAGSMILPQQQQLPQAQQPQQQQQ-----TLPP-----HPHLAQQQQLPP 1090

Human   999 YPLMHHQMPPPHPPQPGQIPGPGSMMPGQHMPGRMIPTVAANIHPSG----------SGPTPPGM 1053
            :|   ||:||...|    :.||    ..||.|  :.|.|.::  |:|          :|..|||.
  Fly  1091 HP---HQLPPQSQP----LAGP----TAQHQP--LPPHVVSS--PNGAPFAAPPISLTGGLPPGA 1140

Human  1054 PPM----PGNILGPRVPLTAPNGMYPPPPQQQPPPPPPADGVPPPPA----PG--PPASAAP 1105
            |..    |.:..|| |...|.....|.|....||...|......||.    ||  |||:.||
  Fly  1141 PTAIVTNPSDQTGP-VAAGAAQSQAPTPMDTTPPSSGPVSDANAPPGSAMPPGGIPPANTAP 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC1	NP_003065.3	MarR-like, BRCT and chromo domains module. /evidence=ECO:0000255|PROSITE-ProRule:PRU01376	28..302		104/275 (38%)
		SWIRM-assoc_2	32..445	CDD:465143	152/447 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..439		45/171 (26%)
		RSC8	444..>710	CDD:227584	193/296 (65%)
		SWIRM-assoc_3	706..772	CDD:465145	35/65 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..860		38/162 (23%)
		SWIRM-assoc_1	883..954	CDD:465142	58/70 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..1028		26/93 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1105		24/83 (29%)
mor	NP_524373.1	SWIRM-assoc_2	6..446	CDD:465143	152/447 (34%)
		RSC8	417..>742	CDD:227584	201/324 (62%)
		SWIRM-assoc_3	738..803	CDD:465145	35/65 (54%)
		DUF4670	<863..1049	CDD:464815	97/185 (52%)
		SWIRM-assoc_1	962..1031	CDD:465142	57/68 (84%)
		PHA03247	<1100..1209	CDD:223021	34/115 (30%)