Protein Alignment SMARCC1 and smarcc1a

DIOPT Version :10

• Sequence 1: NP_003065.3
• Gene: SMARCC1 / 6599
• HGNCID: 11104
• Length: 1105
• Species: Homo sapiens
• Sequence 2: XP_003200294.1
• Gene: smarcc1a / 403020
• ZFINID: ZDB-GENE-080514-3
• Length: 1089
• Species: Danio rerio
• Alignment Length: 1127
• Identity: 791/1127 - (70%)
• Similarity: 899/1127 - (79%)
• Gaps: 72/1127 - (6%)

Human     1 MAAAAGGGGPGTAVGATGSGIAAA---AAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKH 62
            ||.||      ||.|.||||..:|   .||.::.|:|||||::|:|||.||||||::||:|:|||
Zfish     1 MATAA------TAAGGTGSGGPSAGQTGAGSSIGRKKDGGPSSKYWESSETVSQLETVRLWIGKH 59

Human    63 YKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYK 127
            |||:|..|:||:||||.||||||||||||||:.|:|||.||||||.|:|||.|||||||||:|||
Zfish    60 YKKHVQTDSPTSKTLAALVVQLLQFQEDAFGRRVSNPALTKLPAKSFLDFKPGGALCHILGSAYK 124

Human   128 YKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQ 192
            :|:|||||||||||||||||||||||.|||||||||.||||.:|::.|::.|.||||||||||||
Zfish   125 FKSEQGWRRFDLQNPSRMDRNVEMFMTIEKTLVQNNSLTRPIVYIVSDVEQKQANKLKDIIKRHQ 189

Human   193 GTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPP 257
            ||.|::||||:|.|||..:..::||||||||||:||||||||:||||||.||.::||||::||||
Zfish   190 GTITEDKSKATHIIYPSPTQMEEEEWLRPVMRKDKQVLVHWGYYPDSYDIWVSTSDVDADVEDPP 254

Human   258 IPEKPWKVHVKWILDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANA 322
            ..||||:||.||::|||.|||||||||||||||:|||||||||....:...|:|:|::||:....
Zfish   255 SSEKPWRVHAKWVIDTDAFNEWMNEEDYEVDENKKPVSFRQRIFPGEDVSSRTPDRKERKSLVAG 319

Human   323 RKRKHSPSPPPPTPTESRKKSGKKGQASLYGKRRSQKEEDEQ-EDLTKDMEDPTPVPNIEEVVLP 386
            :||:.||| ||.||.||||| ||||......:||.|..:||| ||.|||:|||:|||.:|||.||
Zfish   320 KKRRRSPS-PPSTPVESRKK-GKKGNPGSQWRRRGQPIDDEQDEDSTKDLEDPSPVPGMEEVTLP 382

Human   387 KNVNLKKDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNVTEQTNHIII 451
            ||||.||||||||||||...|||:|::::||:|||||::.:|.:.:|.:| .||||||||:||||
Zfish   383 KNVNQKKDSENTPVKGGIHNDLDDQEDDSVTSGGKEDDEQSKAEVNRLID-SEDNVTEQTHHIII 446

Human   452 PSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLT 516
            ||||:|||||.||.||||||||||||||||||||||||||||||||||||||||||||:||||||
Zfish   447 PSYAAWFDYNSIHEIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTSCRRNLT 511

Human   517 GDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQ 581
            ||||||||||||||||||||||||.||||:.||||||.||||||||||||||||.|.||||.|||
Zfish   512 GDVCAVMRVHAFLEQWGLVNYQVDAESRPLPMGPPPTSHFNVLADTPSGLVPLHHRPPQVPPAQQ 576

Human   582 MLNFPEKNKEKPVDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVS 646
            |||||||.|:||.|||||||||||||||.| |.|||:.||:||||||||||||||||||||||||
Zfish   577 MLNFPEKGKDKPTDLQNFGLRTDIYSKKNL-KGKGAAGGRDWTEQETLLLLEALEMYKDDWNKVS 640

Human   647 EHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVA 711
            ||||||||||||||||||||||.|||:||||||||||||:|||||||||||||||||||||||||
Zfish   641 EHVGSRTQDECILHFLRLPIEDQYLESSDASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVA 705

Human   712 SAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGA 776
            :|||||||:||||||||||.|||||||||||||||::|||||.:|||||.||||.|:||||.|..
Zfish   706 AAAAKAALDEFSRVREEVPAELVEAHVKKVQEAARSTGKVDPAFGLESSGIAGTAPEEPEKTEPT 770

Human   777 EEEKMEADPDGQQPEKAENKVENE--TDEGDKAQDGENEK-------NSEKEQDSEVSEDTKSEE 832
            |.|||:.|.|.|||:|||:|.|.|  ::..:|..:.|.||       ..::|::||..| ||:.|
Zfish   771 ETEKMDTDSDSQQPDKAESKDEAEKPSESAEKPAETEKEKIETTEKSEPQEEEESEAGE-TKTAE 834

Human   833 KETEENKELTDTCK--ERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSL 895
            ||.||..|.|:..|  |.|.:.||||:|.:|.|||:|||||||||||||||||||||||||||||
Zfish   835 KEKEEAMETTEEGKEDEEEQEEGKKKLELDIGEGNIATAAAAALASAATKAKHLAAVEERKIKSL 899

Human   896 VALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQ 960
            |||||||||||||:||||||||||||||||||||.||||||||||.||||||||||::|||||||
Zfish   900 VALLVETQMKKLELKLRHFEELETIMDREKEALELQRQQLLTERQAFHMEQLKYAEMKARQQMEQ 964

Human   961 Q---------QHGQNPQQAHQHSGGPGLAPLGAAGHPGMMPHQQPPPYPLMHHQMPPPHPPQPGQ 1016
            |         .||..|     |...||:.|    |||| .|....|.:|.|||.|.|.|.||.|.
Zfish   965 QAAVQQNAGGHHGPPP-----HGPPPGMHP----GHPG-HPGHPGPGFPPMHHPMGPHHTPQTGP 1019

Human  1017 IPGPGSMMPGQHMPGRMIPTVAANIHPSGSGPTPP-GMPPMPGNILGPRVPLTAPNGMYPPPPQQ 1080
            :.|     |||.|||||:           |||.|. |:.||    :|||.| ..||||||.|
Zfish  1020 MVG-----PGQPMPGRMM-----------SGPPPQGGIAPM----MGPRHP-GPPNGMYPGP--- 1060

Human  1081 QPPPPPPADGVPPPPAPGPPAS 1102
             |||....||:||.|. |||.|
Zfish  1061 -PPPTAQPDGMPPGPV-GPPPS 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC1	NP_003065.3	MarR-like, BRCT and chromo domains module. /evidence=ECO:0000255|PROSITE-ProRule:PRU01376	28..302		205/273 (75%)
		SWIRM-assoc_2	32..445	CDD:465143	285/413 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..439		80/143 (56%)
		RSC8	444..>710	CDD:227584	241/265 (91%)
		SWIRM-assoc_3	706..772	CDD:465145	55/65 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..860		62/125 (50%)
		SWIRM-assoc_1	883..954	CDD:465142	66/70 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..1028		32/80 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1105		30/63 (48%)
smarcc1a	XP_003200294.1	SWIRM-assoc_2	29..440	CDD:465143	285/413 (69%)
		RSC8	439..>704	CDD:227584	241/265 (91%)
		SWIRM-assoc_3	700..760	CDD:465145	51/59 (86%)
		SWIRM-assoc_1	887..958	CDD:465142	66/70 (94%)